{"id":"W2755543134","doi":"10.21037/atm.2017.08.38","title":"Very early antiretroviral therapy permits CD8 T cells to keep HIV reservoirs at bay","year":2017,"lang":"en","type":"letter","venue":"Annals of Translational Medicine","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"McGill University; Canadian Institutes of Health Research; Canadian Foundation for AIDS Research; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"CD8; Antiretroviral therapy; Immunology; Human immunodeficiency virus (HIV); Immune system; Cytotoxic T cell; T cell; Medicine; Cell; Virus; Virology; Viral replication; Viral load; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0003878006,0.0004081628,0.0008131929,0.0003179013,0.000305488,0.00001201907,0.0006661315,0.0007549567,0.003231383],"category_scores_gemma":[0.0001062872,0.0003035022,0.0002697612,0.0001015485,0.0006445993,0.0001042217,0.00005175679,0.0009650951,0.001944844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002378463,"about_ca_system_score_gemma":0.0001599191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002714917,"about_ca_topic_score_gemma":0.00002536719,"domain_scores_codex":[0.9976125,0.000275012,0.0005205272,0.0005450876,0.0003576612,0.0006892253],"domain_scores_gemma":[0.998085,0.0005798348,0.0002313599,0.0006975188,0.0003218157,0.00008449722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008234193,0.00007718273,0.003111519,0.00007547783,0.0007741522,0.0002309791,0.0005521909,0.000002709901,0.02553065,0.00001174494,0.9645255,0.004284523],"study_design_scores_gemma":[0.002261253,0.002070739,0.01707729,0.0004046123,0.00005348506,0.00002373708,0.00000754125,4.161587e-7,0.01217866,0.0001289201,0.9655252,0.0002681952],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.1137933,0.01448872,0.00001569486,0.8625231,0.0008716356,0.000777928,0.002129445,0.00003669692,0.005363438],"genre_scores_gemma":[0.6123379,0.004811478,0.0001202543,0.2172111,0.003594022,0.0001558441,0.01531101,0.0001615514,0.1462968],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.6453121,"threshold_uncertainty_score":0.9999417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07845396378269005,"score_gpt":0.3376002186933896,"score_spread":0.2591462549106995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}