{"id":"W2755556020","doi":"10.1385/cp:1:1:045","title":"New targets for an old drug","year":2004,"lang":"en","type":"article","venue":"Clinical Proteomics","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Muscular Dystrophy Canada","funders":"","keywords":"Proteomics; Mechanism of action; Drug; Mechanism (biology); Computational biology; Drug discovery; Methotrexate; Rheumatoid arthritis; Docking (animal); Pharmacology; Bioinformatics; Medicine; Biology; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003379001,0.001324857,0.00246986,0.001662144,0.00134883,0.004265953,0.001416714,0.003437129,0.01900293],"category_scores_gemma":[0.002436372,0.000434726,0.001299688,0.0009529868,0.003191388,0.008675933,0.002128252,0.006320588,0.00712411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002365435,"about_ca_system_score_gemma":0.002414674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004591363,"about_ca_topic_score_gemma":0.001128262,"domain_scores_codex":[0.9986427,0.0004011696,0.0001170587,0.0002200915,0.0003770721,0.0002420097],"domain_scores_gemma":[0.9974073,0.0008031672,0.0001927715,0.0003263088,0.0007097247,0.0005607561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002878699,0.001201254,0.003042638,0.002410608,0.0003114128,0.001965252,0.00041127,0.0009746479,0.03235859,0.1122616,0.1741437,0.6680403],"study_design_scores_gemma":[0.000653149,0.002250504,0.002186792,0.0008579973,0.0003212872,0.002686112,0.0004185996,0.001245352,0.01015946,0.07231135,0.9068052,0.0001042785],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.0253442,0.5476568,0.02926768,0.3086972,0.02072465,0.0003368567,0.001195954,0.0009852862,0.06579144],"genre_scores_gemma":[0.2208792,0.4508091,0.02849088,0.1481175,0.03810525,0.0006349431,0.001803557,0.0004371589,0.1107224],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01900293,"threshold_uncertainty_score":0.06357116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04688815417757575,"score_gpt":0.3867028397041745,"score_spread":0.3398146855265987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}