{"id":"W2755556020","doi":"10.1385/cp:1:1:045","title":"New targets for an old drug","year":2004,"lang":"en","type":"article","venue":"Clinical Proteomics","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Muscular Dystrophy Canada","funders":"","keywords":"Proteomics; Mechanism of action; Drug; Mechanism (biology); Computational biology; Drug discovery; Methotrexate; Rheumatoid arthritis; Docking (animal); Pharmacology; Bioinformatics; Medicine; Biology; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004451587,0.0001375795,0.0001716696,0.00001552592,0.00006671304,0.00002852131,0.0003451695,0.0002788428,0.00001030053],"category_scores_gemma":[0.0004972647,0.0001236943,0.0002172603,0.00004731849,0.0001095098,0.000003752483,0.0001469281,0.0002047969,0.00002529618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000124079,"about_ca_system_score_gemma":0.0002532629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000369401,"about_ca_topic_score_gemma":0.00002506835,"domain_scores_codex":[0.9986895,0.00004356265,0.0003269186,0.0005028324,0.0001121859,0.0003250431],"domain_scores_gemma":[0.9990096,0.00001686966,0.00006009241,0.0004457256,0.0000923579,0.0003753676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005807176,0.0003113442,0.0003294805,0.00002740293,0.000052159,0.000002479779,0.00001514191,0.00003157305,0.9723062,0.001270576,0.01383864,0.01123431],"study_design_scores_gemma":[0.002450482,0.001007789,0.0001972398,0.0000105995,0.00001290432,0.000004584419,0.000008129306,0.00002594143,0.9155951,0.01030403,0.07014075,0.0002425223],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8505816,0.0003799979,0.1452901,0.001807139,0.0002551276,0.001158603,0.00002549009,0.00003035152,0.0004716033],"genre_scores_gemma":[0.8025415,0.0002221297,0.1863834,0.003186648,0.002429703,0.0001425285,0.0004245742,0.00007976457,0.004589771],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05671116,"threshold_uncertainty_score":0.5044108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04688815417757575,"score_gpt":0.3867028397041745,"score_spread":0.3398146855265987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}