{"id":"W2755578884","doi":"10.1038/s41467-017-00628-y","title":"The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Health and Medical Research Council; Australian Research Council; National Heart, Lung, and Blood Institute; Medical Research Council; State Government of Victoria","keywords":"AMPK; Phosphorylation; Autophagy; ULK1; Cell biology; Protein kinase A; AMP-activated protein kinase; Chemistry; Kinase; Biology; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001266956,0.0003101826,0.0004333947,0.0001936687,0.0001714182,0.0002363381,0.0001614784,0.000230891,0.002324601],"category_scores_gemma":[0.0001739379,0.0001681705,0.0002298729,0.0001555238,0.000211893,0.0002263204,0.0002475504,0.0006623883,0.0005247471],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002581225,"about_ca_system_score_gemma":0.0001399907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001412032,"about_ca_topic_score_gemma":0.000284061,"domain_scores_codex":[0.999897,0.00001873903,0.00001232585,0.00002238249,0.00002208452,0.00002755368],"domain_scores_gemma":[0.9999058,0.00002079209,0.00003120848,0.00001883638,0.000006699493,0.00001668448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006996928,0.00007105841,0.0002574814,0.0000695527,0.00000909102,0.0000735361,0.00001963338,0.0001522926,0.9952615,0.0001663938,0.0001317956,0.003087918],"study_design_scores_gemma":[0.00003932169,0.0004217929,0.001985427,0.000004829481,0.00001089508,0.0001779388,0.00001078193,0.0004657411,0.9952056,0.0001007357,0.001572829,0.000004227842],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931305,0.002039275,0.001496111,0.000298149,0.00008288614,0.00003200992,0.0002002294,0.0001785367,0.002542339],"genre_scores_gemma":[0.9960265,0.001046195,0.001127866,0.0001357588,0.00002147345,0.0000295866,0.0001954769,0.00002287376,0.001394278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002324601,"threshold_uncertainty_score":0.007776618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01504493329264077,"score_gpt":0.3214074736868603,"score_spread":0.3063625403942195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}