{"id":"W2755591022","doi":"10.1002/mds.27122","title":"Design optimization for clinical trials in early‐stage manifest Huntington's disease","year":2017,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Wellcome Trust; Medical Research Council; University College London Hospitals NHS Foundation Trust; National Institute for Health and Care Research; CHDI Foundation","keywords":"Sample size determination; Covariate; Observational study; Clinical trial; Randomization; Randomized controlled trial; Interim; Outcome (game theory); Interim analysis; Research design; Generalizability theory; Medicine; Statistics; Psychology; Physical therapy; Internal medicine; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.2249817,0.002177442,0.003862585,0.001785614,0.0007552537,0.003107162,0.001847824,0.002983859,0.007500514],"category_scores_gemma":[0.3615126,0.001473767,0.003905335,0.001222665,0.001858599,0.003032874,0.002765233,0.003664997,0.001272797],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00211452,"about_ca_system_score_gemma":0.005757688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004398182,"about_ca_topic_score_gemma":0.0006743884,"domain_scores_codex":[0.5865572,0.3908765,0.00997515,0.005571899,0.005710521,0.001308612],"domain_scores_gemma":[0.6568015,0.2872978,0.02430705,0.01989933,0.009416693,0.002277645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.09402528,0.003233746,0.01837838,0.01854108,0.01353597,0.0007232817,0.002135998,0.1693529,0.005979673,0.1024334,0.01258913,0.5590712],"study_design_scores_gemma":[0.08643518,0.07546038,0.02160198,0.008909494,0.01332887,0.0008741598,0.0008245609,0.3309301,0.009765632,0.337348,0.1139247,0.0005971098],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.05267563,0.006847464,0.834157,0.004761017,0.001266092,0.088503,0.001207443,0.001147777,0.009434427],"genre_scores_gemma":[0.2186604,0.001423418,0.6565772,0.002349446,0.0002655853,0.1187329,0.0004575613,0.0001250355,0.001408471],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.2249817,"threshold_uncertainty_score":0.9557356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2181434294801863,"score_gpt":0.4225772042398251,"score_spread":0.2044337747596388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}