{"id":"W2755598222","doi":"10.3390/pharmaceutics9030035","title":"Pharmacokinetic and Toxicodynamic Characterization of a Novel Doxorubicin Derivative","year":2017,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Manitoba","funders":"National Cancer Institute","keywords":"Doxorubicin; Pharmacokinetics; Derivative (finance); Pharmacology; Chemistry; Medicine; Internal medicine; Chemotherapy; Economics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001031359,0.0001397869,0.000153987,0.00009304757,0.00006359377,0.0001632424,0.00008721509,0.0001462016,0.0005790938],"category_scores_gemma":[0.0001663139,0.00009114176,0.0001336227,0.00006750722,0.0001140947,0.0001213179,0.00007211261,0.0002836702,0.0001430322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003062474,"about_ca_system_score_gemma":0.0001720757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006893825,"about_ca_topic_score_gemma":0.0008755765,"domain_scores_codex":[0.9999442,0.000007744271,0.000002872387,0.00001816607,0.0000194174,0.00000761341],"domain_scores_gemma":[0.9999372,0.00001315468,0.00002200932,0.000005038302,0.00001063238,0.00001191481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002762429,0.00004718479,0.0005318517,0.00002429805,0.00000632538,0.00004829827,0.00001199385,0.0002946986,0.9959601,0.0000333747,0.00005217404,0.002713449],"study_design_scores_gemma":[0.00009313568,0.003889334,0.01311337,0.000008324574,0.00004996274,0.0006037704,0.00002575683,0.01081453,0.9676908,0.00004928191,0.003644219,0.00001754354],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949072,0.0008910879,0.003431861,0.00005813899,0.00001657859,0.00003087785,0.0001327585,0.00002380828,0.0005076274],"genre_scores_gemma":[0.9957482,0.0006213278,0.001690125,0.00004825061,0.000008537141,0.00002995394,0.0002115426,0.00001111867,0.001630942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006893825,"threshold_uncertainty_score":0.002222002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06312581859176919,"score_gpt":0.3715612689328562,"score_spread":0.308435450341087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}