{"id":"W2755598222","doi":"10.3390/pharmaceutics9030035","title":"Pharmacokinetic and Toxicodynamic Characterization of a Novel Doxorubicin Derivative","year":2017,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Manitoba","funders":"National Cancer Institute","keywords":"Doxorubicin; Pharmacokinetics; Derivative (finance); Pharmacology; Chemistry; Medicine; Internal medicine; Chemotherapy; Economics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001238494,0.0001159157,0.0002233961,0.00006012253,0.0001195537,0.00002423372,0.00007779697,0.00006052645,0.00003042365],"category_scores_gemma":[0.00004970984,0.0001139049,0.00005028121,0.00004987101,0.0001439125,0.0001429721,0.00004297031,0.0001427664,0.00000190447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003293435,"about_ca_system_score_gemma":0.00003728163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000631423,"about_ca_topic_score_gemma":7.357652e-7,"domain_scores_codex":[0.9993471,0.00001415327,0.0001847033,0.0001612331,0.0001563317,0.0001364615],"domain_scores_gemma":[0.9993552,0.00002134556,0.0002029959,0.0002291298,0.00009689211,0.00009443614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001082749,0.0001194897,0.002575526,0.0001301855,0.00008368716,0.000003100668,0.0003739792,0.000002531944,0.9757469,0.0001062819,0.000005712658,0.02074438],"study_design_scores_gemma":[0.0033552,0.00005580404,0.04708608,0.00008984665,0.000153878,0.00003936179,0.00002283231,0.01104796,0.9363875,0.00002160363,0.001640415,0.00009945953],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993186,0.00005419194,0.003779853,0.001204543,0.0001250491,0.0003816614,0.00003184037,0.00002676888,0.001210118],"genre_scores_gemma":[0.9978229,0.0005817794,0.0005032191,0.0007379088,0.0001321907,0.000009209723,0.00003251548,0.00001939591,0.0001608219],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04451056,"threshold_uncertainty_score":0.4644908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06312581859176919,"score_gpt":0.3715612689328562,"score_spread":0.308435450341087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}