{"id":"W2755614830","doi":"10.1136/annrheumdis-2017-eular.5664","title":"FRI0050 Type ii collagen secreted from articular chondrocytes is mainly destroyed by cathepsin s in ra mice","year":2017,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Instituto de Salud Carlos III; Canadian Institutes of Health Research; Instituto Nacional De Salud Pública; Universidad de León; Amgen Canada; Amgen; Instituto de Seguriidad y Servicios Sociales de los Trabadores del Estado; Consejo Nacional de Ciencia y Tecnología","keywords":"Type II collagen; Chemistry; Cartilage; Synovial membrane; Cell biology; Cathepsin S; Type I collagen; Molecular biology; Synovial fluid; Arthritis; Cathepsin; Immunology; Pathology; Osteoarthritis; Biology; Medicine; Anatomy; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005420067,0.001381815,0.0008461532,0.002926778,0.0004730884,0.001097131,0.000666459,0.001727346,0.004446898],"category_scores_gemma":[0.0004110801,0.001014655,0.001419247,0.0006031489,0.001614184,0.0009093506,0.0004139261,0.002350094,0.001458569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008444791,"about_ca_system_score_gemma":0.0006563613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0023114,"about_ca_topic_score_gemma":0.0022988,"domain_scores_codex":[0.999054,0.0001130674,0.0001429481,0.0002199131,0.000227097,0.0002429891],"domain_scores_gemma":[0.9986361,0.0001212794,0.0006354406,0.000107411,0.00007405381,0.0004257367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00117954,0.00007194741,0.0002488015,0.00005009517,0.00002163926,0.0002306209,0.00002668521,0.00004345032,0.997352,0.0001271958,0.00005498715,0.0005929806],"study_design_scores_gemma":[0.0002349879,0.00107678,0.007877185,0.00001607236,0.0001120981,0.0019446,0.0001413584,0.000717387,0.9855202,0.0001612735,0.002173905,0.00002419298],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888816,0.004214852,0.002930976,0.0004553444,0.000121698,0.00003622793,0.00132088,0.0004124737,0.00162599],"genre_scores_gemma":[0.9865747,0.001161593,0.001611761,0.0001749875,0.00005383417,0.0000690799,0.001103134,0.0001513444,0.009099574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004446898,"threshold_uncertainty_score":0.01487637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03307213278199225,"score_gpt":0.3170423389652386,"score_spread":0.2839702061832464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}