{"id":"W2755644324","doi":"10.1158/0008-5472.can-17-0496","title":"LSD1-Mediated Epigenetic Reprogramming Drives CENPE Expression and Prostate Cancer Progression","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto; University Health Network; Ontario Institute for Cancer Research; Genome British Columbia; Princess Margaret Cancer Centre","funders":"National Cancer Institute","keywords":"Reprogramming; Prostate cancer; Epigenetics; Cancer research; Cancer; Chromatin; Epigenetic therapy; Androgen receptor; Biology; Androgen deprivation therapy; Regulator; Medicine; Gene expression; DNA methylation; Cell; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000116693,0.0001714749,0.0001216424,0.0002131971,0.0001891528,0.0003839885,0.0001791627,0.0001808159,0.00247832],"category_scores_gemma":[0.00007397198,0.0001220165,0.0001726073,0.0001206961,0.0003321464,0.0001354025,0.0003059647,0.0005471482,0.0005844435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005358561,"about_ca_system_score_gemma":0.0003313917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000946842,"about_ca_topic_score_gemma":0.001582212,"domain_scores_codex":[0.9999076,0.00001263632,0.000005351453,0.0000228295,0.00002449664,0.00002701124],"domain_scores_gemma":[0.9999413,0.000007616773,0.00001982027,0.000009492281,0.000004541231,0.00001717193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001342224,0.00003215892,0.0007648615,0.00003460671,0.000006121656,0.00007479505,0.00001801935,0.0001164343,0.9953744,0.0005066877,0.0002269395,0.002710812],"study_design_scores_gemma":[0.00002345056,0.0001692332,0.01219743,0.000007508944,0.00001323218,0.0004921064,0.00006014134,0.001336462,0.9786944,0.0002061788,0.006791641,0.00000824907],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844258,0.002957417,0.004537983,0.0004215672,0.00007024752,0.00003178457,0.001118276,0.0004109193,0.006025922],"genre_scores_gemma":[0.9958975,0.0004033055,0.0005503748,0.00004022891,0.000004337734,0.000007960528,0.0003319901,0.00001355607,0.002750781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00247832,"threshold_uncertainty_score":0.008290827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09539327455615022,"score_gpt":0.4810607586295137,"score_spread":0.3856674840733635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}