{"id":"W2755752847","doi":"10.1038/leu.2017.290","title":"Generation of a multi-antigen-directed immune response for durable control of acute lymphoblastic leukemia","year":2017,"lang":"en","type":"letter","venue":"Leukemia","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; BC Children's Hospital","funders":"Canadian Institutes of Health Research","keywords":"Lymphoblastic Leukemia; Immune system; Immunology; Antigen; Medicine; Acute lymphocytic leukemia; Leukemia; Asparaginase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000540885,0.0002580537,0.0004372463,0.0001579032,0.0003917795,0.0007584181,0.0003698755,0.00299409,0.00211635],"category_scores_gemma":[0.001277308,0.0001082138,0.000264094,0.00008912188,0.000598121,0.0005438448,0.0003979988,0.003668915,0.0009340054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008557905,"about_ca_system_score_gemma":0.0002720716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001172286,"about_ca_topic_score_gemma":0.0002525616,"domain_scores_codex":[0.9997064,0.0001030866,0.00002176404,0.00002982746,0.00007253893,0.00006617871],"domain_scores_gemma":[0.9996463,0.0002303669,0.00002454394,0.00002758347,0.00003441026,0.00003669281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002597034,0.001058633,0.00494523,0.0009560758,0.0001224782,0.02447834,0.0002775906,0.002812,0.07121123,0.06475606,0.4015805,0.4252048],"study_design_scores_gemma":[0.001497154,0.00206607,0.002028316,0.0001321226,0.0001107201,0.02445131,0.0001997582,0.008277627,0.06350072,0.02937016,0.8683247,0.00004135351],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.1472129,0.0391786,0.0162417,0.7216323,0.02737957,0.0003469847,0.0002163674,0.0005200379,0.04727151],"genre_scores_gemma":[0.7458107,0.01714664,0.008192705,0.1761328,0.02470189,0.0004284299,0.0002124639,0.0001035143,0.02727077],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.00299409,"threshold_uncertainty_score":0.007079899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04461783480646685,"score_gpt":0.3200980018113587,"score_spread":0.2754801670048918,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}