{"id":"W2755783416","doi":"10.1093/molehr/gax050","title":"Treatment with AICAR inhibits blastocyst development, trophectoderm differentiation and tight junction formation and function in mice","year":2017,"lang":"en","type":"article","venue":"Molecular Human Reproduction","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Lawson Health Research Institute; Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Blastocyst; Biology; Blastocoel; Embryo; Andrology; Protein kinase A; Internal medicine; Endocrinology; Embryogenesis; Cell biology; Phosphorylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007318106,0.0006764624,0.00107171,0.0008598603,0.0003231156,0.0005348922,0.0005633523,0.0008207877,0.004141875],"category_scores_gemma":[0.0003406298,0.0004773157,0.000926218,0.0003846476,0.0004904666,0.000461728,0.0002877715,0.001415221,0.001390418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003995219,"about_ca_system_score_gemma":0.0004800066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003669313,"about_ca_topic_score_gemma":0.001006444,"domain_scores_codex":[0.9993655,0.0001261358,0.00009539758,0.000144075,0.0001558093,0.0001130333],"domain_scores_gemma":[0.9995186,0.00005729355,0.0001961012,0.00005464826,0.00003749703,0.000135767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002663241,0.0004468706,0.001295441,0.0005247166,0.0000803718,0.0002203909,0.00006341867,0.0001577346,0.9861476,0.0002580937,0.0005641006,0.007577979],"study_design_scores_gemma":[0.000528038,0.00717379,0.0145646,0.0001205524,0.0002715171,0.000760631,0.0001150471,0.0006920662,0.9669321,0.0001739722,0.008638676,0.00002893444],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9554814,0.02048604,0.01062724,0.0008649181,0.0003215763,0.0007259296,0.003957545,0.0007584176,0.006776905],"genre_scores_gemma":[0.948121,0.01863863,0.01216092,0.0008690167,0.0001618003,0.00174022,0.002651163,0.0001852533,0.01547191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004141875,"threshold_uncertainty_score":0.01385593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01014876423053777,"score_gpt":0.2258917652576263,"score_spread":0.2157430010270886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}