{"id":"W2755800927","doi":"10.1124/jpet.117.242099","title":"Preclinical Pharmacology and Pharmacokinetics of Inhaled Hexadecyl-Treprostinil (C16TR), a Pulmonary Vasodilator Prodrug","year":2017,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Theratechnologies (Canada)","funders":"","keywords":"Pharmacology; Pharmacokinetics; Prodrug; Medicine; Cmax; Treprostinil; Hypoxic pulmonary vasoconstriction; Prostaglandin; Inhalation; Vasodilation; Lung; Pulmonary hypertension; Anesthesia; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003400694,0.0004065669,0.0004044705,0.0002081884,0.000133037,0.0003551923,0.0002555555,0.0003973411,0.001221106],"category_scores_gemma":[0.0003064791,0.0002266223,0.0003246475,0.0001299499,0.0002550512,0.0003566713,0.00008319291,0.000995231,0.0004764716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003781055,"about_ca_system_score_gemma":0.0005284018,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006201636,"about_ca_topic_score_gemma":0.0006575778,"domain_scores_codex":[0.9998599,0.00003347833,0.00001166602,0.00002300245,0.00004067194,0.00003121494],"domain_scores_gemma":[0.9997994,0.0000365249,0.00006532259,0.00002264736,0.00003336043,0.00004272801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004589356,0.001805137,0.0007204794,0.0001247497,0.0000370665,0.0001320821,0.0000418563,0.001262285,0.9681543,0.00009997653,0.0003779849,0.02265471],"study_design_scores_gemma":[0.00085688,0.07546437,0.008208408,0.00002527782,0.0001422544,0.0008403521,0.0000647138,0.003433254,0.9040224,0.00009027161,0.006825926,0.00002591181],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887642,0.003466039,0.004186585,0.0001798583,0.00007343905,0.0004447686,0.0008105185,0.0001845383,0.001889992],"genre_scores_gemma":[0.9879375,0.003516291,0.003406299,0.0001872194,0.00006641077,0.0003304245,0.001242183,0.00004800686,0.003265678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001221106,"threshold_uncertainty_score":0.004085064,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04643744621003545,"score_gpt":0.4089930397407995,"score_spread":0.3625555935307641,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}