{"id":"W2755874011","doi":"10.1016/j.bmc.2017.09.024","title":"The compound (3-{5-[(2,5-dimethoxyphenyl)amino]-1,3,4-thiadiazolidin-2-yl}-5,8-methoxy-2H-chromen-2-one) inhibits the prion protein conversion from PrPC to PrPSc with lower IC50 in ScN2a cells","year":2017,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Docking (animal); Prion protein; Small molecule; Chemical library; Stereochemistry; Native chemical ligation; Biophysics; Biochemistry; Chemical synthesis; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001388804,0.0003178486,0.0003926312,0.0004192552,0.0002130512,0.0002237325,0.0003352002,0.0005262844,0.003064888],"category_scores_gemma":[0.00009842154,0.0001510781,0.0002415216,0.0002113047,0.0002549109,0.0001593978,0.0001548413,0.000528531,0.0008655887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002663341,"about_ca_system_score_gemma":0.0004151729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008996341,"about_ca_topic_score_gemma":0.001734748,"domain_scores_codex":[0.9999226,0.00001063735,0.000005209126,0.00001631964,0.00001724313,0.00002782187],"domain_scores_gemma":[0.9999479,0.000008142588,0.00001196979,0.000005674438,0.00000583214,0.00002047408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004180438,0.00009321522,0.000136587,0.0001815962,0.00001555946,0.0002121209,0.00002831982,0.0001568268,0.9923051,0.0003537057,0.0003721978,0.005726728],"study_design_scores_gemma":[0.0004845292,0.005654905,0.008268193,0.0000339748,0.00009283781,0.001396746,0.00004664471,0.0009321134,0.969236,0.0001534734,0.01366483,0.00003575279],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9721191,0.009422832,0.005082395,0.0006034337,0.0005019846,0.000161715,0.00118813,0.0006188673,0.01030151],"genre_scores_gemma":[0.9888892,0.0030228,0.002782929,0.0002152248,0.00009533144,0.00006378534,0.0006393982,0.0000175972,0.004273724],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003064888,"threshold_uncertainty_score":0.01025313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01268592883779025,"score_gpt":0.2451220836309422,"score_spread":0.2324361547931519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}