{"id":"W2755934370","doi":"10.1038/gim.2017.147","title":"Fragile X testing as a second-tier test","year":2017,"lang":"en","type":"letter","venue":"Genetics in Medicine","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children's Hospital of Eastern Ontario; University of Ottawa","funders":"","keywords":"Autism; Autism spectrum disorder; Fragile X syndrome; Medicine; Genetic testing; Test (biology); Population; Fragile x; Family history; Pediatrics; Diagnostic test; Medical genetics; Clinical history; Psychiatry; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002005286,0.0006623688,0.0009923266,0.0008777476,0.002202339,0.002796029,0.001444101,0.03559576,0.004719536],"category_scores_gemma":[0.01577595,0.0005507956,0.001229706,0.0004006103,0.002070345,0.002329166,0.001269923,0.02436225,0.003496756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002861757,"about_ca_system_score_gemma":0.002636714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002922324,"about_ca_topic_score_gemma":0.008092448,"domain_scores_codex":[0.9976872,0.00064563,0.0002667572,0.0003119659,0.0006356595,0.0004527353],"domain_scores_gemma":[0.9945349,0.00313029,0.0002059437,0.0002492836,0.0006868191,0.001192829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001733045,0.0001548303,0.00797478,0.00005015065,0.0000455473,0.06181457,0.0001379942,0.0004976866,0.001177798,0.01374029,0.8728307,0.04140231],"study_design_scores_gemma":[0.0005032304,0.0005575994,0.009356797,0.0006056988,0.0001556366,0.1496326,0.0007213412,0.006254132,0.003249819,0.08500163,0.7437258,0.0002357336],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.00372216,0.00172263,0.001478864,0.9621056,0.01904648,0.00004087572,0.0001056989,0.0001093815,0.0116683],"genre_scores_gemma":[0.03507692,0.001871026,0.001854443,0.8728683,0.07421343,0.00006730531,0.0001188451,0.00007003106,0.0138597],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.03559576,"threshold_uncertainty_score":0.02076358,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02618882247591393,"score_gpt":0.2785111480493879,"score_spread":0.252322325573474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}