{"id":"W2756264987","doi":"10.1016/j.molcel.2017.08.013","title":"mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1","year":2017,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":396,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; Montreal Neurological Institute and Hospital; McGill University","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Vetenskapsrådet; Howard Hughes Medical Institute; Cancerfonden; Canadian Diabetes Association; Medical Research Council; Terry Fox Research Institute","keywords":"Mitochondrial fission; Biology; mTORC1; Cell biology; PI3K/AKT/mTOR pathway; mitochondrial fusion; RPTOR; Mitochondrion; GTPase; Mitochondrial biogenesis; mTORC2; Signal transduction; Mitochondrial DNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002034033,0.0004363585,0.0003007428,0.0004492908,0.0006444879,0.001100568,0.0004855218,0.0006214135,0.003733951],"category_scores_gemma":[0.0002626021,0.0002232688,0.0002587321,0.0002495678,0.0004814432,0.0008705736,0.0005535935,0.0008176659,0.001331699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009887579,"about_ca_system_score_gemma":0.0003349948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001057817,"about_ca_topic_score_gemma":0.001943067,"domain_scores_codex":[0.9998069,0.00001467893,0.0000135368,0.00005732888,0.00005391485,0.00005365167],"domain_scores_gemma":[0.9998356,0.00001457128,0.00005411509,0.00001368099,0.00002615849,0.00005584854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000577013,0.00005144946,0.0006888606,0.0001009033,0.00001239254,0.0001293232,0.0000424315,0.0001749327,0.9860297,0.003337228,0.0008991053,0.007956726],"study_design_scores_gemma":[0.00003376574,0.0001613813,0.009547674,0.0000176324,0.00002147294,0.0004738514,0.0001010545,0.002322649,0.9727888,0.0009732285,0.01354228,0.00001619068],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9608024,0.00722234,0.009192361,0.00229678,0.0002459381,0.00004586098,0.002293704,0.000732578,0.01716815],"genre_scores_gemma":[0.9898008,0.001226695,0.001722384,0.0001193515,0.00003876078,0.00002697973,0.0006844092,0.0001002458,0.006280414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003733951,"threshold_uncertainty_score":0.01249135,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006634367875222086,"score_gpt":0.2241190761943282,"score_spread":0.2174847083191061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}