{"id":"W2756264987","doi":"10.1016/j.molcel.2017.08.013","title":"mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1","year":2017,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":396,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; Montreal Neurological Institute and Hospital; McGill University","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Vetenskapsrådet; Howard Hughes Medical Institute; Cancerfonden; Canadian Diabetes Association; Medical Research Council; Terry Fox Research Institute","keywords":"Mitochondrial fission; Biology; mTORC1; Cell biology; PI3K/AKT/mTOR pathway; mitochondrial fusion; RPTOR; Mitochondrion; GTPase; Mitochondrial biogenesis; mTORC2; Signal transduction; Mitochondrial DNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001119117,0.0002369755,0.0002408083,0.000034738,0.0002758935,0.000114652,0.0003291153,0.000312591,0.00007253764],"category_scores_gemma":[0.00008060189,0.000240818,0.0001236519,0.00001819607,0.0001553353,0.000005822089,0.0002193915,0.0001509038,0.00006952899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000124773,"about_ca_system_score_gemma":0.00005050464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000443973,"about_ca_topic_score_gemma":0.00008567813,"domain_scores_codex":[0.9986801,0.0001079977,0.0002089403,0.0005350691,0.0001421881,0.0003256729],"domain_scores_gemma":[0.9987006,0.00001126495,0.0001681087,0.0008738997,0.00007542929,0.00017075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001905805,0.00005891079,0.0008833906,0.00001789985,0.00002026772,0.00004906423,0.00001401228,0.00001301328,0.9964751,0.0001656718,0.001041607,0.001070505],"study_design_scores_gemma":[0.004871073,0.0006373679,0.0006236919,0.00000610637,0.00007126093,0.00003298496,0.0000425142,0.0007205875,0.856622,0.0001652332,0.1355992,0.0006079982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7461816,0.001015086,0.1904854,0.0004476764,0.004795687,0.0006687611,0.00009686645,0.00003970512,0.05626923],"genre_scores_gemma":[0.9863592,0.0001037925,0.00358837,0.0005403802,0.0007590433,0.00002936083,0.000230761,0.00005775797,0.008331267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2401777,"threshold_uncertainty_score":0.9820271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006634367875222086,"score_gpt":0.2241190761943282,"score_spread":0.2174847083191061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}