{"id":"W2756272086","doi":"10.1007/s10549-017-4476-1","title":"The expected benefit of preventive mastectomy on breast cancer incidence and mortality in BRCA mutation carriers, by age at mastectomy","year":2017,"lang":"en","type":"article","venue":"Breast Cancer Research and Treatment","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":false,"ca_institutions":"Public Health Ontario; Women's College Hospital","funders":"","keywords":"Mastectomy; Prophylactic Mastectomy; Breast cancer; Medicine; Incidence (geometry); BRCA mutation; Oncology; Cancer; Internal medicine; Gynecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002255515,0.0001782054,0.0001811353,0.00005652814,0.0005188337,0.00008716327,0.0001991786,0.000089382,0.00003659879],"category_scores_gemma":[0.00002229777,0.0001293273,0.00003950819,0.00009117274,0.000571472,0.00001682235,0.0002033656,0.000101105,8.948301e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005878186,"about_ca_system_score_gemma":0.0002687755,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.01350553,"about_ca_topic_score_gemma":0.03871156,"domain_scores_codex":[0.9985473,0.0001049073,0.0001920841,0.0004893398,0.0003129087,0.0003535081],"domain_scores_gemma":[0.9989927,0.00004439906,0.0001355799,0.0005147512,0.0001929352,0.0001195922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003167043,0.0003404046,0.7403131,0.00007975535,0.0007682345,0.00006040564,0.0009709306,0.00009733476,0.06372049,0.0001016675,0.000749649,0.189631],"study_design_scores_gemma":[0.002172571,0.000347446,0.9407511,0.0001068457,0.00002720489,0.00004016951,0.0002781267,0.00002797019,0.05515875,0.0001612037,0.0007828439,0.0001457188],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927099,0.004328021,0.000002963256,0.0007985379,0.00005829745,0.0005883769,0.00126376,0.000003985177,0.0002461667],"genre_scores_gemma":[0.9935423,0.004494674,0.00001508873,0.00001140512,0.00008107285,0.0007292129,0.0000509319,0.00001870785,0.001056625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2004381,"threshold_uncertainty_score":0.9930636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02942241028155653,"score_gpt":0.3634506063564046,"score_spread":0.3340281960748481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}