{"id":"W2756332356","doi":"10.1128/aac.01695-17","title":"Antiviral Activity of Bictegravir and Cabotegravir against Integrase Inhibitor-Resistant SIVmac239 and HIV-1","year":2017,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Dolutegravir; Elvitegravir; Raltegravir; Integrase; Virology; Integrase inhibitor; Biology; Simian immunodeficiency virus; Pharmacology; Human immunodeficiency virus (HIV); Viral load; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001567958,0.0003447738,0.0003016134,0.0002820074,0.0001569422,0.0002093301,0.0002760089,0.0003234945,0.001028837],"category_scores_gemma":[0.0001472201,0.0001383315,0.000198283,0.0001016767,0.0001819324,0.000131241,0.0001031579,0.0004511078,0.0001786182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002803371,"about_ca_system_score_gemma":0.0001505976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001276428,"about_ca_topic_score_gemma":0.001693096,"domain_scores_codex":[0.999846,0.00003925555,0.00001408513,0.00001856272,0.00004498319,0.00003713792],"domain_scores_gemma":[0.9999175,0.0000203619,0.00001499319,0.00001142361,0.00001267661,0.00002300148],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004353874,0.0001537263,0.000324017,0.00004336553,0.00001447198,0.00003640516,0.00001891044,0.0003305662,0.9961995,0.00006383177,0.0000794559,0.002300334],"study_design_scores_gemma":[0.00003834752,0.003218946,0.003391874,0.000007954642,0.00002041232,0.0002271345,0.00002762964,0.001676825,0.9898643,0.00004228998,0.001475489,0.000008719742],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970233,0.001225376,0.0003730342,0.00002785886,0.00001610125,0.00002051842,0.0002881259,0.00002936393,0.0009964053],"genre_scores_gemma":[0.9965186,0.0004674567,0.001001137,0.00003043908,0.00000707901,0.00002480346,0.0005353847,0.000009688048,0.001405375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001276428,"threshold_uncertainty_score":0.003441811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01299183663220307,"score_gpt":0.2671527514997447,"score_spread":0.2541609148675416,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}