{"id":"W2756347613","doi":"10.18632/oncotarget.21003","title":"Atorvastatin downregulates co-inhibitory receptor expression by targeting Ras-activated mTOR signalling","year":2017,"lang":"en","type":"article","venue":"Oncotarget","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Atorvastatin; PI3K/AKT/mTOR pathway; Downregulation and upregulation; Receptor; Cancer immunotherapy; Immune system; T cell; Immunotherapy; Biology; Cancer research; Effector; Cell biology; Signal transduction; Medicine; Immunology; Pharmacology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001522785,0.0003095719,0.0003554793,0.0002953187,0.0001827558,0.0004159892,0.0002616429,0.0002512153,0.002510384],"category_scores_gemma":[0.0001369671,0.0001552302,0.0004179193,0.0002319952,0.0002501958,0.0002407663,0.0002282891,0.0007439991,0.0009067528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003045912,"about_ca_system_score_gemma":0.0005163126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008943374,"about_ca_topic_score_gemma":0.002067618,"domain_scores_codex":[0.9998142,0.00002445194,0.00001938202,0.00002435988,0.00004193169,0.00007560203],"domain_scores_gemma":[0.9999367,0.000007640775,0.00001982193,0.000007767564,0.00001015709,0.00001798812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002666472,0.0003764666,0.001197674,0.0003031052,0.00007220874,0.0001604556,0.00003484062,0.0001938046,0.9764646,0.0005088952,0.001564569,0.01645701],"study_design_scores_gemma":[0.0008340837,0.003529268,0.03126739,0.00006770956,0.0003635692,0.0006145267,0.0002209111,0.003771828,0.9341239,0.0004142558,0.02475839,0.00003425128],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979903,0.01059766,0.002153707,0.0006568372,0.0002315493,0.00007984504,0.0007973349,0.0003539473,0.005226136],"genre_scores_gemma":[0.9877802,0.004797748,0.0009312566,0.0001713234,0.00005697342,0.00008998471,0.0007868881,0.0000320714,0.005353467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002510384,"threshold_uncertainty_score":0.008398116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01620187261016697,"score_gpt":0.2936024544964858,"score_spread":0.2774005818863188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}