{"id":"W2756391540","doi":"10.1038/leu.2017.284","title":"RSK2 is a new Pim2 target with pro-survival functions in FLT3-ITD-positive acute myeloid leukemia","year":2017,"lang":"en","type":"article","venue":"Leukemia","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Cancer Research; Institut National Du Cancer","keywords":"Fms-Like Tyrosine Kinase 3; Myeloid leukemia; Biology; Ribosomal s6 kinase; Cancer research; Kinase; Gene knockdown; Ectopic expression; Cytarabine; Apoptosis; Cell biology; Signal transduction; Protein kinase B; Gene; P70-S6 Kinase 1; Genetics; Mutation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002407555,0.0004341442,0.0004303558,0.0003288434,0.000376653,0.0006779695,0.0004049398,0.0003010193,0.002744308],"category_scores_gemma":[0.0001397931,0.0001375826,0.0003588036,0.0003188994,0.0002371726,0.0002990356,0.0003332432,0.0008478202,0.000902126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006515833,"about_ca_system_score_gemma":0.0003875325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004215022,"about_ca_topic_score_gemma":0.001053763,"domain_scores_codex":[0.9998908,0.00001426358,0.000008345539,0.0000155703,0.0000405849,0.00003041989],"domain_scores_gemma":[0.9999688,0.000003167869,0.000006069047,0.000003490849,0.00000558593,0.00001285922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002848416,0.0005277039,0.00307266,0.0006267909,0.0001862664,0.00122544,0.00008618371,0.002125728,0.8679666,0.002787984,0.007684585,0.1108617],"study_design_scores_gemma":[0.001174854,0.002365836,0.0144948,0.00004903701,0.0004388384,0.005020911,0.0001290658,0.00676816,0.8720428,0.0008651651,0.09657771,0.00007292223],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.950778,0.0166748,0.004756962,0.001819765,0.0004173644,0.000198321,0.001631959,0.0006162853,0.02310652],"genre_scores_gemma":[0.9869617,0.004465157,0.002124244,0.0003445942,0.00005745049,0.00007745716,0.001651248,0.00003040721,0.004287705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002744308,"threshold_uncertainty_score":0.009180665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01693530138355899,"score_gpt":0.2750778082306718,"score_spread":0.2581425068471129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}