{"id":"W2756414786","doi":"10.1101/190207","title":"A blood-based signature of cerebrospinal fluid A <i>β</i> <sub>1–42</sub> status","year":2017,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; BioClinica; F. Hoffmann-La Roche; University of Southern California; Biogen; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Cerebrospinal fluid; Dementia; Amyloid (mycology); Cohort; Amyloid beta; Neuroimaging; β amyloid; Positron emission tomography","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004543315,0.0004330701,0.000423909,0.0007729315,0.0001363614,0.0007079172,0.0002066864,0.0004572937,0.0005733253],"category_scores_gemma":[0.00183938,0.0001019641,0.0002096823,0.0004560378,0.000177228,0.0002688115,0.0001928743,0.0003339104,0.0003423161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001772165,"about_ca_system_score_gemma":0.0002039055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001244351,"about_ca_topic_score_gemma":0.000961834,"domain_scores_codex":[0.9997806,0.00006228918,0.00001820555,0.0000602206,0.0000559784,0.00002262992],"domain_scores_gemma":[0.9991411,0.0002603336,0.0002572672,0.00006632465,0.0001975786,0.00007732921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003242271,0.0003736047,0.6229057,0.0001974486,0.0003365861,0.001033002,0.0001920859,0.01509513,0.2361203,0.0005951881,0.00266315,0.1172456],"study_design_scores_gemma":[0.00005603083,0.001200692,0.5802497,0.00005835621,0.0002352166,0.003352039,0.0001678873,0.2994706,0.1108382,0.0017868,0.002475797,0.0001086658],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9734933,0.0004627036,0.02296434,0.0001277138,0.00004049185,0.0000270661,0.001681098,0.0003810155,0.0008223101],"genre_scores_gemma":[0.9910732,0.0001177284,0.007778113,0.00004749247,0.00002466802,0.00001407043,0.0006845809,0.00001815644,0.0002420161],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001244351,"threshold_uncertainty_score":0.002474248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01344779266651931,"score_gpt":0.2562571679706557,"score_spread":0.2428093753041364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}