{"id":"W2757190301","doi":"10.1182/blood-2017-06-788349","title":"Confirmed efficacy of etoposide and dexamethasone in HLH treatment: long-term results of the cooperative HLH-2004 study","year":2017,"lang":"en","type":"article","venue":"Blood","topic":"Autoimmune and Inflammatory Disorders Research","field":"Medicine","cited_by":661,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Barncancerfonden; Vetenskapsrådet; Karolinska Institutet; Insamlingsstiftelsen Cancer- och Allergifonden","keywords":"Etoposide; Dexamethasone; Hemophagocytic lymphohistiocytosis; Medicine; Internal medicine; Immunology; Oncology; Chemotherapy; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004963841,0.0002915217,0.0008029501,0.0005242467,0.0003426405,0.0007427177,0.0004564418,0.0004671112,0.0005774884],"category_scores_gemma":[0.003279783,0.0001314063,0.0006296511,0.0006736125,0.0002774246,0.0005808428,0.0004559079,0.0005719984,0.0002198754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006364805,"about_ca_system_score_gemma":0.0005675347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00263735,"about_ca_topic_score_gemma":0.003662873,"domain_scores_codex":[0.9984769,0.0008164386,0.0001706757,0.0001658917,0.0002346887,0.0001353448],"domain_scores_gemma":[0.9969822,0.0008572784,0.0009098351,0.0003859015,0.0004105261,0.0004543507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.01948313,0.001188106,0.9371251,0.0001172417,0.001274601,0.0003157431,0.0001760019,0.000343058,0.003699718,0.00006166693,0.0007155051,0.03550013],"study_design_scores_gemma":[0.0009869285,0.008983001,0.9840349,0.00006133456,0.001101814,0.0003886618,0.0001589205,0.0001961782,0.00138154,0.00004630924,0.002641582,0.00001876592],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923131,0.005159452,0.0001762294,0.0001116711,0.00002985681,0.00006902539,0.0008691518,0.000008194721,0.001263358],"genre_scores_gemma":[0.9973468,0.0006355366,0.0001519154,0.00009118676,0.00004789786,0.00003061787,0.001362018,0.000004003759,0.0003299322],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004963841,"threshold_uncertainty_score":0.02625161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03750387943550386,"score_gpt":0.3427169274531296,"score_spread":0.3052130480176257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}