{"id":"W2757416034","doi":"10.1016/j.bbabio.2017.09.005","title":"Metabolic control by sirtuins and other enzymes that sense NAD+, NADH, or their ratio","year":2017,"lang":"en","type":"review","venue":"Biochimica et Biophysica Acta (BBA) - Bioenergetics","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":210,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"H2020 European Research Council; Institute of Aging; National Institute on Aging; Carlsbergfondet; National Institute on Alcohol Abuse and Alcoholism; Novo Nordisk Fonden; American Heart Association; Ellison Medical Foundation","keywords":"NAD+ kinase; Enzyme; Sense (electronics); Biochemistry; Chemistry; Metabolic control analysis; Biology; Biotechnology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004142849,0.0008968453,0.001302914,0.001363808,0.0002064878,0.0009047795,0.0007764024,0.0008134281,0.002677849],"category_scores_gemma":[0.00036416,0.0002351726,0.0005281893,0.001535076,0.0004648319,0.0009620943,0.0005637885,0.001335044,0.001712837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003988229,"about_ca_system_score_gemma":0.0005961228,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008102198,"about_ca_topic_score_gemma":0.002060157,"domain_scores_codex":[0.9998623,0.00002390448,0.00002231045,0.00002630494,0.00005032035,0.00001491999],"domain_scores_gemma":[0.9998736,0.00004505107,0.00002600152,0.000005932928,0.00003826951,0.00001117345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002015329,0.00007627152,0.0004630862,0.01914129,0.0002471282,0.0002982673,0.00009104875,0.0004079409,0.009295589,0.005102031,0.01469504,0.9499808],"study_design_scores_gemma":[0.0000306445,0.0001153156,0.001364926,0.001489809,0.000227602,0.001175166,0.00009452322,0.0001072321,0.002897079,0.002608896,0.9898605,0.00002832559],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003009869,0.9976763,0.0002950702,0.0002295512,0.0002000769,0.000004545807,0.000028755,0.000010203,0.001254516],"genre_scores_gemma":[0.001950459,0.9965301,0.0003272176,0.0001414994,0.0001455931,0.000005456398,0.000062322,0.000001516505,0.000835874],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002677849,"threshold_uncertainty_score":0.00895834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0974883376531529,"score_gpt":0.3623604766712809,"score_spread":0.264872139018128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}