{"id":"W2757471682","doi":"10.1016/j.cjca.2017.07.057","title":"OVER-EXPRESSION OF MYBL2 REJUVENATES EXPLANT DERIVED CARDIAC STEM CELLS FROM AGED DONORS WITH ISCHEMIC CARDIOMYOPATHY","year":2017,"lang":"en","type":"article","venue":"Canadian Journal of Cardiology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Medicine; Telomere; Transcriptome; Stem cell; Senescence; Ischemic cardiomyopathy; Oxidative stress; Myocardial infarction; Internal medicine; Telomerase; Andrology; Gene expression; Immunology; Cell biology; Heart failure; Gene; Biology; Genetics; Ejection fraction","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002441339,0.0002877426,0.0003794989,0.0002200107,0.0002052011,0.000457486,0.0002432978,0.0004589893,0.00449706],"category_scores_gemma":[0.00009478627,0.0001806551,0.0002742878,0.0001439743,0.0002428614,0.0002546344,0.0002543848,0.0010524,0.0009927716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001251421,"about_ca_system_score_gemma":0.0001798749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003862427,"about_ca_topic_score_gemma":0.000823578,"domain_scores_codex":[0.9997949,0.00001693024,0.00002552317,0.00006316315,0.00004101435,0.00005848342],"domain_scores_gemma":[0.9998698,0.0000195205,0.00002647597,0.00001389774,0.000009916142,0.00006044405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001162648,0.00005019804,0.0001456928,0.00001943169,0.00000507921,0.00008795666,0.00002783705,0.00002333749,0.9987331,0.0000772263,0.00006044037,0.0006534001],"study_design_scores_gemma":[0.00005936736,0.0004485407,0.007650311,0.00001321607,0.00004576494,0.0007262186,0.0001419326,0.0007607883,0.9849874,0.0000744615,0.005082543,0.000009328584],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936511,0.0008560555,0.00247173,0.0001395395,0.0001716074,0.00003992739,0.0007410016,0.00009477152,0.00183427],"genre_scores_gemma":[0.9885249,0.0004725122,0.001659875,0.0001274908,0.00002991773,0.00004925845,0.001072045,0.00005349137,0.008010545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00449706,"threshold_uncertainty_score":0.01504415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0069391787822307,"score_gpt":0.2256805036805092,"score_spread":0.2187413248982785,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}