{"id":"W2757504452","doi":"10.1021/jacs.7b07582","title":"4′-<i>C</i>-Methoxy-2′-deoxy-2′-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing","year":2017,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Chemistry; Epimer; Nuclease; Stereochemistry; RNA interference; Gene silencing; Intramolecular force; Substituent; RNA; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001439543,0.0004451558,0.0003199567,0.0001161282,0.00008505118,0.0001982207,0.0002536623,0.0003244922,0.0009012655],"category_scores_gemma":[0.0001874087,0.0001747053,0.0002733104,0.00007664513,0.0001476762,0.000172551,0.0001243734,0.0003340021,0.0004350384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002310908,"about_ca_system_score_gemma":0.0001488652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004345276,"about_ca_topic_score_gemma":0.000594691,"domain_scores_codex":[0.9998816,0.00002899264,0.00001058812,0.00002806547,0.00002363192,0.00002709676],"domain_scores_gemma":[0.9999114,0.00001674936,0.00003288012,0.000009982499,0.00001403333,0.00001483217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004735286,0.00001186702,0.00005858176,0.00001987383,0.000003080117,0.00003373342,0.000006269684,0.0003022203,0.9984634,0.00008046769,0.00001394537,0.0009591478],"study_design_scores_gemma":[0.000008014988,0.0002060979,0.0003662163,0.000001764377,0.000007580149,0.00006896419,0.000003156352,0.0007548665,0.9973489,0.00001373426,0.00121534,0.000005313542],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850534,0.001102445,0.01033324,0.00005355937,0.0000318737,0.00005946965,0.0001724363,0.0001256964,0.003068038],"genre_scores_gemma":[0.9883483,0.000399,0.009083321,0.00005837402,0.00001194247,0.00004104189,0.0001704731,0.00002762126,0.001859911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009012655,"threshold_uncertainty_score":0.003014982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01291089377129865,"score_gpt":0.2581176848701119,"score_spread":0.2452067910988133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}