{"id":"W2757608129","doi":"10.3791/56373","title":"Real-time Quaking-induced Conversion Assay for Detection of CWD Prions in Fecal Material","year":2017,"lang":"en","type":"article","venue":"Journal of Visualized Experiments","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Food Inspection Agency; University of Calgary","funders":"Alberta Agriculture and Forestry; Genome Canada; National Institutes of Health; Genome Alberta; University of Calgary","keywords":"Feces; Chronic wasting disease; Chemistry; Recombinant DNA; Microbiology; Thioflavin; Molecular biology; Biology; Chromatography; Biochemistry; Virology; Prion protein; Scrapie; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004247839,0.0001006208,0.0002207809,0.00006633559,0.0001139363,0.0000404007,0.000210832,0.0001239443,0.00003836671],"category_scores_gemma":[0.0002059466,0.00009289862,0.0001600737,0.00001855489,0.00002901347,0.0000169735,0.00007953375,0.00004587735,0.000001244611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003546587,"about_ca_system_score_gemma":0.0000701836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004935182,"about_ca_topic_score_gemma":0.00000165361,"domain_scores_codex":[0.9991185,0.00008957814,0.0003750438,0.0001272818,0.0001467351,0.000142872],"domain_scores_gemma":[0.9989511,0.00001276873,0.0006496148,0.0001988616,0.0001127208,0.00007493565],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001730813,0.0001238515,0.000361358,0.0000197744,0.0000499719,0.000003193433,0.0000531412,0.000001825357,0.9952897,0.000007139065,0.00007076227,0.00228846],"study_design_scores_gemma":[0.002833933,0.0006957651,0.001695036,0.00007703579,0.00002057922,0.000007616467,0.00005586623,0.0000988051,0.9933752,0.00003074959,0.001013382,0.00009604184],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984044,0.0001891493,0.0007148329,0.0000245777,0.0004036975,0.0002002664,0.00001110379,0.000002211885,0.00004972484],"genre_scores_gemma":[0.9986126,0.0002115007,0.0008892266,0.000013152,0.0002107308,0.000009569186,0.000009515261,0.00001455579,0.00002916675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002192418,"threshold_uncertainty_score":0.3788296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02712645741637244,"score_gpt":0.4149029123430255,"score_spread":0.387776454926653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}