{"id":"W2757770663","doi":"10.1002/ijc.31079","title":"Novel targets for sensitizing breast cancer cells to TRAIL‐induced apoptosis with siRNA delivery","year":2017,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Cure Brain Cancer Foundation; Canadian Institutes of Health Research; Alberta Innovates - Health Solutions","keywords":"Gene silencing; Small interfering RNA; Cancer cell; Apoptosis; Cancer research; Cancer; Programmed cell death; Stromal cell; Breast cancer; Medicine; Biology; Cell culture; Transfection; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002213877,0.0006065525,0.0004629013,0.0004009387,0.0002303307,0.0004064437,0.0003146905,0.0004663714,0.0008789519],"category_scores_gemma":[0.0001157787,0.0002346686,0.0003492652,0.000197325,0.0001756509,0.0002510149,0.0002621531,0.0005027616,0.0005852342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004846345,"about_ca_system_score_gemma":0.0002849637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000410821,"about_ca_topic_score_gemma":0.0009591952,"domain_scores_codex":[0.9997972,0.00003101353,0.00002598964,0.00004231816,0.00007130149,0.00003232338],"domain_scores_gemma":[0.9999261,0.00001089973,0.00001958821,0.000009063093,0.00002240463,0.00001192764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003380522,0.00001978855,0.00003961004,0.00006247844,0.000006588013,0.00002990142,0.00001734386,0.00007944914,0.996623,0.00009972674,0.00007883138,0.002909377],"study_design_scores_gemma":[0.00001627183,0.0001700742,0.0002512652,0.000005292315,0.00002143614,0.0001561889,0.000006656161,0.0006551523,0.9936554,0.00002673566,0.005030104,0.00000548154],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8716629,0.01976858,0.09588721,0.0007054888,0.000303586,0.0008598762,0.001136207,0.001492836,0.008183274],"genre_scores_gemma":[0.9277178,0.009763266,0.04890161,0.0003152374,0.00005518106,0.0008222506,0.001503743,0.0001115601,0.01080937],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008789519,"threshold_uncertainty_score":0.003516257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02037818337209614,"score_gpt":0.3110778372821048,"score_spread":0.2906996539100087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}