{"id":"W2757938450","doi":"10.3389/fonc.2017.00229","title":"Targeting Nucleotide Biosynthesis: A Strategy for Improving the Oncolytic Potential of DNA Viruses","year":2017,"lang":"en","type":"review","venue":"Frontiers in Oncology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society; Canadian Institutes of Health Research; Alberta Innovates; Networks of Centres of Excellence of Canada; Women and Children's Health Research Institute; Children's Health Research Institute","keywords":"Oncolytic virus; Biology; Cancer cell; Biogenesis; Virus; Computational biology; DNA replication; DNA; Gene; Viral replication; Cancer; Virology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003348118,0.0006137391,0.0006391762,0.001708105,0.0002231415,0.0007465848,0.0005175533,0.0009326058,0.00166964],"category_scores_gemma":[0.0003057422,0.0003060443,0.0004131268,0.001127977,0.0004235768,0.001195245,0.0005684905,0.002034666,0.001179039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007805196,"about_ca_system_score_gemma":0.000666975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006149195,"about_ca_topic_score_gemma":0.001150397,"domain_scores_codex":[0.9998878,0.00001641009,0.00001330137,0.00001997976,0.00004805572,0.00001439269],"domain_scores_gemma":[0.9999039,0.00004088877,0.00001489107,0.000004159846,0.00002545742,0.0000105908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000912456,0.000108951,0.0001926022,0.01656812,0.00009445923,0.0003809635,0.0001284387,0.001195529,0.04313034,0.01826038,0.01712569,0.9027233],"study_design_scores_gemma":[0.00001150316,0.00008457537,0.0002826895,0.0009502283,0.0000532764,0.001037921,0.00003251628,0.0001826089,0.008100319,0.002451811,0.9867959,0.0000167058],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005468785,0.9959247,0.001071913,0.0002902387,0.0002231241,0.000007705099,0.00002003294,0.00001764519,0.001897734],"genre_scores_gemma":[0.002651749,0.9949353,0.0009285329,0.0001824165,0.00008531649,0.00001077919,0.00004037598,0.000004245382,0.00116121],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001708105,"threshold_uncertainty_score":0.005663097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06964891683011483,"score_gpt":0.3865192416805044,"score_spread":0.3168703248503896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}