{"id":"W2758088381","doi":"10.1021/acs.jproteome.7b00451","title":"Disease Association and Druggability of WD40 Repeat Proteins","year":2017,"lang":"en","type":"article","venue":"Journal of Proteome Research","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"","keywords":"Druggability; Computational biology; Drug discovery; Allosteric regulation; Protein–protein interaction; Biology; Proteasome; Drug development; Protein domain; Proteome; Genetics; Bioinformatics; Biochemistry; Enzyme; Drug; Pharmacology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002842314,0.0001642569,0.0002367239,0.0006281805,0.0001557147,0.0003486287,0.0001195672,0.0003163196,0.001690129],"category_scores_gemma":[0.0005107487,0.00007087341,0.0001536355,0.0004354464,0.000203998,0.000196592,0.000209543,0.0001791431,0.0002675512],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000185728,"about_ca_system_score_gemma":0.00008578147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002418285,"about_ca_topic_score_gemma":0.0002027823,"domain_scores_codex":[0.9997897,0.00005225935,0.00002568112,0.00005614143,0.00005407829,0.00002217723],"domain_scores_gemma":[0.9997606,0.00005914945,0.00009774722,0.00002594765,0.00002418227,0.0000323619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001214876,0.0001236431,0.08507979,0.000224638,0.0001521083,0.001303837,0.0001099171,0.0008832252,0.8636252,0.002117549,0.0006437136,0.04452158],"study_design_scores_gemma":[0.00009064238,0.001732451,0.579555,0.00006407152,0.0003792369,0.01923918,0.0002098918,0.006821445,0.3613052,0.003639353,0.0269192,0.00004440391],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931436,0.00389117,0.0007562829,0.00009158239,0.000008662701,0.000008601372,0.0004717156,0.0000339645,0.001594502],"genre_scores_gemma":[0.9980394,0.0006975664,0.0003620462,0.0000240185,0.000006372054,0.000005433098,0.0002787493,0.000006180626,0.0005801363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001690129,"threshold_uncertainty_score":0.005654037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05373911888969598,"score_gpt":0.3740494923417904,"score_spread":0.3203103734520944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}