{"id":"W2758088381","doi":"10.1021/acs.jproteome.7b00451","title":"Disease Association and Druggability of WD40 Repeat Proteins","year":2017,"lang":"en","type":"article","venue":"Journal of Proteome Research","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"","keywords":"Druggability; Computational biology; Drug discovery; Allosteric regulation; Protein–protein interaction; Biology; Proteasome; Drug development; Protein domain; Proteome; Genetics; Bioinformatics; Biochemistry; Enzyme; Drug; Pharmacology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004581169,0.00007414444,0.000168162,0.00007909522,0.0002524475,0.00007863733,0.0003467959,0.0001071691,0.00002267786],"category_scores_gemma":[0.005536841,0.00006031346,0.00009433203,0.00004210443,0.0001834302,0.00001681066,0.0002458964,0.0003022402,0.000002256427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004918853,"about_ca_system_score_gemma":0.0003127789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002589085,"about_ca_topic_score_gemma":0.000006640497,"domain_scores_codex":[0.9983975,0.0003207581,0.0003028906,0.0001620264,0.0005871,0.00022968],"domain_scores_gemma":[0.9979349,0.00003750253,0.000492495,0.0004523375,0.0008905727,0.0001922231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005574496,0.0001305029,0.08812588,0.0001862466,0.00005614453,0.00001419629,0.00007480079,8.543278e-7,0.9071557,0.00006599019,0.0006118442,0.003020415],"study_design_scores_gemma":[0.0009668147,0.001079838,0.173519,0.000144687,0.00001445083,0.00001543664,0.00005674004,0.0000183144,0.8131173,0.002767539,0.008185466,0.000114458],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961259,0.0006075249,0.00008210816,0.001682156,0.00004549747,0.0005374536,0.00001851849,0.000001427523,0.0008993535],"genre_scores_gemma":[0.9975737,0.0002256949,0.0009206607,0.000008644129,0.000277121,0.00002658055,0.000002079927,0.000009784701,0.0009557406],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0940384,"threshold_uncertainty_score":0.6628515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05373911888969598,"score_gpt":0.3740494923417904,"score_spread":0.3203103734520944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}