{"id":"W2758103344","doi":"10.1002/bit.26461","title":"Advancements in the design and scalable production of viral gene transfer vectors","year":2017,"lang":"en","type":"review","venue":"Biotechnology and Bioengineering","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canada Research Chairs","keywords":"Viral vector; Biopharmaceutical; Vector (molecular biology); Lentivirus; Virology; Genetic enhancement; SAFER; Technology transfer; Gene transfer; Computational biology; Biotechnology; Biology; Computer science; Virus; Gene; Viral disease; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004130262,0.0001976679,0.0003781808,0.0001621227,0.00006112312,0.00001146152,0.0002683854,0.000498703,8.947441e-7],"category_scores_gemma":[0.00003619965,0.0001403484,0.00005225948,0.00009582441,0.0002020401,0.000003951939,0.0000660873,0.000236857,5.099091e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009722331,"about_ca_system_score_gemma":0.00004131029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002971158,"about_ca_topic_score_gemma":0.000007390017,"domain_scores_codex":[0.9991355,0.00006909795,0.0001983347,0.0003272798,0.00006580969,0.0002040034],"domain_scores_gemma":[0.9995146,0.00001060513,0.00004514304,0.0003985534,0.00001275569,0.00001827733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001157236,0.00003883593,0.000009545301,0.001839693,0.0001510815,0.000005328623,0.00001560469,0.00003478331,0.1487487,0.00002957252,0.00001480815,0.8489963],"study_design_scores_gemma":[0.0004837499,0.00228077,0.0000175303,0.001286027,0.0001627436,0.0001309183,0.00001633822,0.00005305638,0.4297839,0.00002084207,0.5652964,0.0004677378],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02251239,0.9757533,0.0009861594,0.00006306823,0.00008479141,0.0005803361,0.000007113756,0.00001014763,0.000002698138],"genre_scores_gemma":[0.01236754,0.9870625,0.0003723137,0.000004060239,0.00005144,0.00006849392,0.00002237108,0.00001997193,0.00003136763],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8485286,"threshold_uncertainty_score":0.572324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04867903860677932,"score_gpt":0.3240545425159581,"score_spread":0.2753755039091788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}