{"id":"W2758137281","doi":"10.1016/j.canlet.2017.09.012","title":"Long non-coding RNA HNF1A-AS1 mediated repression of miR-34a/SIRT1/p53 feedback loop promotes the metastatic progression of colon cancer by functioning as a competing endogenous RNA","year":2017,"lang":"en","type":"article","venue":"Cancer Letters","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":151,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Science and Technology Commission of Shanghai Municipality; Natural Science Foundation of Shanghai","keywords":"Competing endogenous RNA; Cancer research; Colorectal cancer; Oncogene; Downregulation and upregulation; Gene silencing; Metastasis; Biology; Long non-coding RNA; Psychological repression; Cancer; HNF1A; Tumor progression; Gene expression; Cell cycle; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002230154,0.0003804568,0.0002242504,0.0002372848,0.0002459281,0.0003426344,0.0002616232,0.000280466,0.002282061],"category_scores_gemma":[0.0001754069,0.0001957798,0.0003465936,0.0001071514,0.0004006884,0.0002595037,0.0002211531,0.0007608435,0.0006320665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000405343,"about_ca_system_score_gemma":0.0003227816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006793394,"about_ca_topic_score_gemma":0.001165451,"domain_scores_codex":[0.9997995,0.00003684108,0.000009427401,0.00005360387,0.00005429256,0.00004625899],"domain_scores_gemma":[0.9998779,0.00002079682,0.00002854983,0.00001690896,0.0000186064,0.00003718177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001692337,0.00001997808,0.0001408379,0.00002099302,0.00000367892,0.0000458148,0.00001197875,0.0000666995,0.9981103,0.0002948871,0.00009384651,0.001021737],"study_design_scores_gemma":[0.0000184834,0.0001576597,0.0022958,0.000002378054,0.00001079495,0.0001219827,0.00002207604,0.001687589,0.9936783,0.0001331127,0.00186686,0.000005088837],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988445,0.001687791,0.005608109,0.0004353415,0.0001720889,0.00001973657,0.00031012,0.0003159358,0.003005881],"genre_scores_gemma":[0.9951002,0.0002629615,0.00177022,0.00007230868,0.0000175073,0.00001291799,0.0002343322,0.00003883108,0.002490621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002282061,"threshold_uncertainty_score":0.007634223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02582934509802235,"score_gpt":0.3156326860998941,"score_spread":0.2898033410018717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}