{"id":"W2758335592","doi":"10.1021/acs.jmedchem.7b01192","title":"Inhibition of Calcium Dependent Protein Kinase 1 (CDPK1) by Pyrazolopyrimidine Analogs Decreases Establishment and Reoccurrence of Central Nervous System Disease by <i>Toxoplasma gondii</i>","year":2017,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Toxoplasma gondii Research Studies","field":"Immunology and Microbiology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Structural Genomics Consortium; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences","keywords":"Toxoplasma gondii; Chemistry; Kinase; Central nervous system; Disease; Protein kinase A; Biochemistry; Cell biology; Neuroscience; Genetics; Antibody; Pathology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006104208,0.0002526202,0.00067681,0.00006925945,0.0002258987,0.00002428704,0.0004005812,0.000182047,0.00005640574],"category_scores_gemma":[0.001286652,0.0001985958,0.0001279975,0.00005891397,0.0009908108,0.0001940029,0.0002114478,0.0005543645,0.00000126553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001507459,"about_ca_system_score_gemma":0.0003046882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001604294,"about_ca_topic_score_gemma":0.000005018071,"domain_scores_codex":[0.9980533,0.0001032259,0.0008257396,0.0002605466,0.0003257147,0.0004314867],"domain_scores_gemma":[0.9973625,0.0001442906,0.001503764,0.0003571998,0.0003718012,0.0002604773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00147787,0.0003530588,0.01015773,0.001361036,0.0002244743,0.0001940481,0.000109411,0.000001852761,0.9729168,0.000009498799,0.01210342,0.001090756],"study_design_scores_gemma":[0.002709801,0.0004122801,0.004018042,0.001593423,0.0002092911,0.0003429653,0.0008551333,0.000004791415,0.9888456,0.00001818961,0.0008330299,0.0001574353],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852487,0.01304724,0.00007193284,0.0005073894,0.0001788767,0.0002198038,0.0005206846,0.000009590466,0.0001957794],"genre_scores_gemma":[0.9989933,0.0005108135,0.00003514345,0.0000129467,0.00007255751,0.00001283712,0.00006689514,0.00001231698,0.0002831871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01592877,"threshold_uncertainty_score":0.8098502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01184310139758103,"score_gpt":0.2576577938176662,"score_spread":0.2458146924200852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}