{"id":"W2758335592","doi":"10.1021/acs.jmedchem.7b01192","title":"Inhibition of Calcium Dependent Protein Kinase 1 (CDPK1) by Pyrazolopyrimidine Analogs Decreases Establishment and Reoccurrence of Central Nervous System Disease by <i>Toxoplasma gondii</i>","year":2017,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Toxoplasma gondii Research Studies","field":"Immunology and Microbiology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Structural Genomics Consortium; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences","keywords":"Toxoplasma gondii; Chemistry; Kinase; Central nervous system; Disease; Protein kinase A; Biochemistry; Cell biology; Neuroscience; Genetics; Antibody; Pathology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007538826,0.0002574216,0.0002361241,0.0001405616,0.0001114284,0.0001551125,0.0001945444,0.000178187,0.001529542],"category_scores_gemma":[0.00009504116,0.00008412846,0.0001193577,0.0001034577,0.0001363147,0.0001265338,0.00009133073,0.0003424739,0.0001582211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001934157,"about_ca_system_score_gemma":0.0001830167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006275349,"about_ca_topic_score_gemma":0.001929617,"domain_scores_codex":[0.9999517,0.000008916661,0.000004129191,0.000008219641,0.000008785222,0.00001808901],"domain_scores_gemma":[0.99997,0.000005628868,0.00001186001,0.000001740678,0.000003312258,0.000007554069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001082584,0.0003987365,0.0003132155,0.0001773024,0.00001963539,0.0001282945,0.00002716413,0.00104557,0.9824553,0.00021257,0.0003723909,0.01376713],"study_design_scores_gemma":[0.0004415216,0.01031088,0.004998195,0.00002199343,0.00004675865,0.000436015,0.00002824274,0.001515802,0.9769721,0.0000786079,0.00513276,0.000017202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926525,0.003372052,0.0009991596,0.0001302313,0.0000451084,0.00006419022,0.0003283132,0.0001227451,0.002285711],"genre_scores_gemma":[0.9942212,0.002355801,0.001205089,0.00005763067,0.00001089792,0.00003077833,0.0003589298,0.00000862045,0.001751194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001529542,"threshold_uncertainty_score":0.00511682,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01184310139758103,"score_gpt":0.2576577938176662,"score_spread":0.2458146924200852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}