{"id":"W2758448813","doi":"10.3390/pharmaceutics9040040","title":"Tissue Specific Modulation of cyp2c and cyp3a mRNA Levels and Activities by Diet-Induced Obesity in Mice: The Impact of Type 2 Diabetes on Drug Metabolizing Enzymes in Liver and Extra-Hepatic Tissues","year":2017,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Tolbutamide; Endocrinology; Internal medicine; Cytochrome P450; CYP3A; Microsome; Kidney; Biology; Diabetes mellitus; Type 2 diabetes; Drug metabolism; Enzyme; Metabolism; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002330107,0.0005464741,0.0003450447,0.0005880881,0.0001898267,0.0004349459,0.0001659986,0.0003315014,0.001900379],"category_scores_gemma":[0.0001319867,0.0003048579,0.0005170698,0.0003542259,0.0003623943,0.0002442221,0.0001716043,0.0009782894,0.0003734049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002603616,"about_ca_system_score_gemma":0.0001794133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006577537,"about_ca_topic_score_gemma":0.001516185,"domain_scores_codex":[0.9997048,0.00004558511,0.00003081567,0.00009485172,0.00006826436,0.000055656],"domain_scores_gemma":[0.9997559,0.00002345721,0.00008567918,0.00003972554,0.0000321126,0.00006315322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004189682,0.00005528985,0.0009284376,0.00002556312,0.00001052139,0.00002379933,0.00001144788,0.00002115917,0.9975484,0.00002299326,0.00002236854,0.0009111157],"study_design_scores_gemma":[0.00006336843,0.001109865,0.05294307,0.00001199744,0.0000858907,0.0003037656,0.00005870664,0.0006202839,0.9429094,0.00005382669,0.001829189,0.00001058106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925709,0.001288959,0.00397977,0.0001276048,0.00003386427,0.00004038569,0.001098466,0.00008739196,0.0007726187],"genre_scores_gemma":[0.9818512,0.001707437,0.007301495,0.0002031333,0.00003157062,0.0002328857,0.002541187,0.0001132326,0.006017748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001900379,"threshold_uncertainty_score":0.006357372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1396658508275451,"score_gpt":0.4384056540508882,"score_spread":0.298739803223343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}