{"id":"W2758615270","doi":"10.1161/circulationaha.117.028034","title":"Identification of MicroRNA-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2","year":2017,"lang":"en","type":"article","venue":"Circulation","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":262,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Ottawa Hospital; University of Ottawa","funders":"National Heart, Lung, and Blood Institute; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; National Institute for Health and Care Research; Canadian Institutes of Health Research; National Institutes of Health; British Heart Foundation","keywords":"PKM2; BMPR2; Polypyrimidine tract-binding protein; Glycolysis; Anaerobic glycolysis; Pyruvate kinase; Mitochondrial biogenesis; Downregulation and upregulation; Gene knockdown; Internal medicine; Cancer research; Medicine; Biology; Endocrinology; Cell biology; Alternative splicing; Mitochondrion; Gene isoform; Gene; Biochemistry; Bone morphogenetic protein; Metabolism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001588169,0.0002444413,0.0002944385,0.0001965916,0.0001457893,0.0002986359,0.0001628137,0.0003138016,0.0008314787],"category_scores_gemma":[0.0001652458,0.0001426266,0.0002578225,0.0001067711,0.0001609176,0.0001038287,0.0001456894,0.0004311029,0.0003095073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002359861,"about_ca_system_score_gemma":0.0001849092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002106742,"about_ca_topic_score_gemma":0.0003144449,"domain_scores_codex":[0.9998659,0.00001698625,0.00001057577,0.00004102118,0.00004785098,0.00001768089],"domain_scores_gemma":[0.9998772,0.00001519361,0.00005011354,0.000009249869,0.00002087828,0.00002741555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001599371,0.00002165173,0.00117764,0.00005060523,0.00001346072,0.0001439856,0.00001252103,0.00007236507,0.996605,0.0001072401,0.00009985361,0.001535842],"study_design_scores_gemma":[0.00007599912,0.0004729876,0.0643914,0.00002138131,0.0001301947,0.002149443,0.00005074665,0.005529869,0.9214253,0.0001986609,0.005536449,0.00001768466],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840132,0.003883959,0.008936765,0.000300053,0.00009787121,0.00005233425,0.0008350911,0.0001536515,0.001727123],"genre_scores_gemma":[0.9926943,0.000763143,0.004324169,0.0001609075,0.00002008163,0.00005102579,0.0007698006,0.00002381607,0.001192674],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008314787,"threshold_uncertainty_score":0.00278157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01909920500055955,"score_gpt":0.2693398159950779,"score_spread":0.2502406109945183,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}