{"id":"W2758621921","doi":"10.1016/j.ijrobp.2017.06.238","title":"MGMT Promoter Methylation Status Independently Predicts Overall Survival in Anaplastic Astrocytoma in NRG Oncology/RTOG 9813: A Phase 3 Trial of Radiation Plus Nitrosourea Versus Radiation Plus Temozolomide","year":2017,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôpital Notre-Dame; Université de Montréal; University of Calgary","funders":"","keywords":"Temozolomide; Medicine; Oncology; Internal medicine; Anaplastic astrocytoma; Hazard ratio; Methylation; O-6-methylguanine-DNA methyltransferase; Glioma; Proportional hazards model; Progression-free survival; Chemoradiotherapy; Methyltransferase; Radiation therapy; Astrocytoma; Cancer research; Overall survival; Confidence interval; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001702597,0.001321979,0.002428404,0.0004247318,0.0003275387,0.0009712466,0.0009738337,0.0009606279,0.002123855],"category_scores_gemma":[0.001126797,0.0007041929,0.001705106,0.0006016269,0.000893564,0.0006588111,0.0003354588,0.002507234,0.0006067791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008521752,"about_ca_system_score_gemma":0.001305263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001609053,"about_ca_topic_score_gemma":0.004991097,"domain_scores_codex":[0.9995255,0.0002313632,0.00002741278,0.00008589667,0.00005464603,0.00007512152],"domain_scores_gemma":[0.9992747,0.0002017066,0.0001779462,0.00005860822,0.00004111007,0.0002459109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8581332,0.0163355,0.03323582,0.0003413016,0.003054205,0.0000823298,0.0002227732,0.002476234,0.02251329,0.00009092052,0.002151737,0.06136271],"study_design_scores_gemma":[0.3398278,0.4742066,0.1595436,0.00007495022,0.006221864,0.0005013864,0.000257727,0.007571221,0.0089011,0.0004573188,0.002327167,0.0001092148],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988382,0.0005155047,0.00005864048,0.0001265119,0.00003871056,0.00007433069,0.0001573797,0.00001664282,0.0001740658],"genre_scores_gemma":[0.9973615,0.0006755522,0.0003188805,0.000156759,0.00006503522,0.0001779178,0.0006409534,0.00001944212,0.000584039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002428404,"threshold_uncertainty_score":0.009004295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04106706604326583,"score_gpt":0.3768842080216855,"score_spread":0.3358171419784197,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}