{"id":"W2758796129","doi":"10.1152/ajpcell.00176.2017","title":"Differential localization and anabolic responsiveness of mTOR complexes in human skeletal muscle in response to feeding and exercise","year":2017,"lang":"en","type":"article","venue":"American Journal of Physiology-Cell Physiology","topic":"Muscle metabolism and nutrition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Biotechnology and Biological Sciences Research Council; Directorate for Biological Sciences; Canada Research Chairs; Society for Endocrinology; Universität Basel; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Colocalization; PI3K/AKT/mTOR pathway; P70-S6 Kinase 1; mTORC1; Wheat germ agglutinin; Mechanistic target of rapamycin; Skeletal muscle; Internal medicine; Biology; Endocrinology; mTORC2; Sirolimus; Cell biology; Molecular biology; Signal transduction; Biochemistry; Medicine; Lectin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002724783,0.0001543383,0.0005648707,0.0002444759,0.00009875868,0.00001121748,0.0002309379,0.00008543091,0.000007651092],"category_scores_gemma":[0.0001503704,0.000144602,0.00006085321,0.00008967386,0.0006201865,0.00001739969,0.0001838622,0.0001259387,2.500064e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001175799,"about_ca_system_score_gemma":0.00004848548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001502711,"about_ca_topic_score_gemma":0.00002979336,"domain_scores_codex":[0.9986529,0.0003819109,0.0003983561,0.0002796192,0.00006866807,0.000218513],"domain_scores_gemma":[0.9989669,0.00004964306,0.0005205925,0.0002592314,0.0001023981,0.0001012884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003095314,0.0001217596,0.001363816,0.00003678106,0.00001009463,0.000002171635,0.0001817544,0.0001362774,0.992395,0.00001539433,0.00002952279,0.002612126],"study_design_scores_gemma":[0.001700565,0.001409757,0.8490949,0.00007215975,0.00001467729,0.000005182781,0.000255266,0.00004652832,0.1466694,0.000307856,0.0002868809,0.0001368487],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993598,0.0002723003,0.00004733102,0.00008874542,0.00008882705,0.0001245237,0.00001136392,0.000001469935,0.000005568725],"genre_scores_gemma":[0.9991008,0.0004819833,0.0001652877,0.00007134614,0.0001416619,0.000006154543,0.00001271227,0.00001428175,0.000005796103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8477311,"threshold_uncertainty_score":0.5896699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008294071483395437,"score_gpt":0.2657069521784132,"score_spread":0.2574128806950178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}