{"id":"W2758796129","doi":"10.1152/ajpcell.00176.2017","title":"Differential localization and anabolic responsiveness of mTOR complexes in human skeletal muscle in response to feeding and exercise","year":2017,"lang":"en","type":"article","venue":"American Journal of Physiology-Cell Physiology","topic":"Muscle metabolism and nutrition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Biotechnology and Biological Sciences Research Council; Directorate for Biological Sciences; Canada Research Chairs; Society for Endocrinology; Universität Basel; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Colocalization; PI3K/AKT/mTOR pathway; P70-S6 Kinase 1; mTORC1; Wheat germ agglutinin; Mechanistic target of rapamycin; Skeletal muscle; Internal medicine; Biology; Endocrinology; mTORC2; Sirolimus; Cell biology; Molecular biology; Signal transduction; Biochemistry; Medicine; Lectin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001739714,0.0001214435,0.0002251648,0.0002669552,0.000157756,0.000264828,0.00008037223,0.000181542,0.001203533],"category_scores_gemma":[0.00013336,0.0002025216,0.000206345,0.0002486963,0.0001675514,0.0001365821,0.0001789798,0.0002202755,0.0003085348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001391748,"about_ca_system_score_gemma":0.0001197706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001009837,"about_ca_topic_score_gemma":0.001474252,"domain_scores_codex":[0.9998505,0.00002539568,0.00001331902,0.0000456015,0.00003098485,0.00003408782],"domain_scores_gemma":[0.9999397,0.00001363287,0.00001252629,0.000006305382,0.00001178499,0.00001608828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001294621,0.00004846069,0.003369738,0.00005085233,0.00001945488,0.0001059576,0.00009534457,0.00003472715,0.9921551,0.0000315125,0.00006432585,0.002729898],"study_design_scores_gemma":[0.00006504262,0.001417621,0.6572492,0.00001650592,0.00008536965,0.001104357,0.0005056044,0.001387089,0.3358553,0.00008445074,0.002210389,0.00001901051],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978186,0.001100926,0.0003099852,0.00002255385,0.000007383617,0.000009320023,0.0001516517,0.000007993429,0.0005714929],"genre_scores_gemma":[0.9944779,0.0009235548,0.000759081,0.00005143277,0.00001421509,0.0000697464,0.0006039923,0.000009426589,0.003090655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001203533,"threshold_uncertainty_score":0.004026234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008294071483395437,"score_gpt":0.2657069521784132,"score_spread":0.2574128806950178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}