{"id":"W2759212233","doi":"10.1038/s41467-017-00761-8","title":"High-throughput RNA structure probing reveals critical folding events during early 60S ribosome assembly in yeast","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; Engineering and Physical Sciences Research Council; Canadian Institutes of Health Research; Vetenskapsrådet; University of Edinburgh; Natural Sciences and Engineering Research Council of Canada; Wellcome Trust","keywords":"Ribosomal RNA; Ribosome; RNA; Ribosome biogenesis; Computational biology; 5.8S ribosomal RNA; Biology; Ribosomal protein; Eukaryotic Ribosome; Eukaryotic Large Ribosomal Subunit; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002625313,0.0002040169,0.0002302998,0.0002377182,0.0001910717,0.000360801,0.0002136978,0.0002250405,0.0002861499],"category_scores_gemma":[0.00026053,0.0001948007,0.0002118421,0.0002059316,0.0001776348,0.0002001203,0.0001816391,0.0003007067,0.0001637433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004057896,"about_ca_system_score_gemma":0.0002074364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001287628,"about_ca_topic_score_gemma":0.002903884,"domain_scores_codex":[0.9998562,0.00001354077,0.0000087811,0.00004674554,0.00005803939,0.00001659635],"domain_scores_gemma":[0.9998587,0.00004957155,0.00003118565,0.00002175962,0.0000188612,0.00001981081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001085023,0.00001336663,0.001245437,0.00002040576,0.000007398587,0.00002485318,0.00002641165,0.0006484947,0.9947181,0.0001000817,0.00004380398,0.003043214],"study_design_scores_gemma":[0.00001054361,0.0001358987,0.01983525,0.000002567474,0.00001207857,0.00007752046,0.0000331229,0.009484601,0.969373,0.0001544878,0.0008657828,0.0000150691],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913483,0.0004072617,0.007117298,0.00003759645,0.000007489596,0.0000100451,0.0005334413,0.0001820434,0.000356514],"genre_scores_gemma":[0.979742,0.0004748856,0.01764575,0.00008228252,0.000006501182,0.00002251879,0.001205211,0.00006691499,0.0007539203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001287628,"threshold_uncertainty_score":0.002944231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01809127266534763,"score_gpt":0.3130168274846055,"score_spread":0.2949255548192579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}