{"id":"W2759898910","doi":"10.1016/j.biocel.2017.09.020","title":"The neuroprotective role of rosiglitazone in advanced glycation end product treated human neural stem cells is PPARgamma-dependent","year":2017,"lang":"en","type":"article","venue":"The International Journal of Biochemistry & Cell Biology","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University; Ontario Institute for Cancer Research","funders":"Fu Jen Catholic University; Ministry of Science and Technology","keywords":"Rosiglitazone; Neuroprotection; SOD2; Peroxisome proliferator-activated receptor; TFAM; Agonist; Advanced glycation end-product; Glycation; Pharmacology; Neural stem cell; Biology; Receptor; Endocrinology; Internal medicine; Mitochondrial biogenesis; Medicine; Oxidative stress; Cell biology; Mitochondrion; Stem cell; Superoxide dismutase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000114401,0.0003349954,0.0003507175,0.0002737801,0.0002348117,0.0004078201,0.0002131557,0.0003507322,0.001872595],"category_scores_gemma":[0.00008665561,0.0001167371,0.0003724496,0.0002320052,0.000203764,0.000219559,0.0001605594,0.0009109175,0.0003867482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002273759,"about_ca_system_score_gemma":0.0004862668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001069898,"about_ca_topic_score_gemma":0.002173253,"domain_scores_codex":[0.9999288,0.000008795416,0.000008806444,0.0000110097,0.00001588658,0.00002666556],"domain_scores_gemma":[0.9999415,0.00000858629,0.0000117987,0.00001266588,0.00001266825,0.00001286011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001805414,0.0002801567,0.0005722892,0.0001458135,0.00006454557,0.0003122999,0.00006317894,0.0001359565,0.9849764,0.0006000826,0.0002897019,0.01075426],"study_design_scores_gemma":[0.0001166932,0.001135689,0.006991027,0.0000282725,0.0001291367,0.0002556536,0.0001762733,0.0003378173,0.9864884,0.0003312037,0.004002668,0.000007200661],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883095,0.006156859,0.001407903,0.0003873146,0.0001773876,0.00002537109,0.000486263,0.00009142564,0.002957978],"genre_scores_gemma":[0.9922591,0.00318172,0.0005199075,0.00009580028,0.00001817867,0.00003809378,0.0005681189,0.0000136063,0.003305538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001872595,"threshold_uncertainty_score":0.006264448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007646803408976759,"score_gpt":0.2578006468831374,"score_spread":0.2501538434741606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}