{"id":"W2759926442","doi":"10.1016/j.omtn.2017.08.017","title":"Control of HIV Infection In Vivo Using Gene Therapy with a Secreted Entry Inhibitor","year":2017,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Sunnybrook Health Science Centre; Sunnybrook Hospital; University of Toronto","funders":"Krembil Foundation; Canadian Institutes of Health Research; Canadian Foundation for AIDS Research","keywords":"Genetic enhancement; Progenitor cell; Ex vivo; Biology; Haematopoiesis; Virology; CD34; In vivo; Gene delivery; Glycoprotein; Viral vector; Stem cell; Immunology; Molecular biology; Gene; Cell biology; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001591486,0.0002000777,0.0003145966,0.0001265348,0.0002176243,0.00003229422,0.0002002983,0.0001868628,0.0003663645],"category_scores_gemma":[0.00001734711,0.0001496374,0.00009809707,0.00007910495,0.0002693521,0.00009778511,0.00003132474,0.0001991521,0.00005083633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006152954,"about_ca_system_score_gemma":0.0000858054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005909358,"about_ca_topic_score_gemma":0.00003035715,"domain_scores_codex":[0.9988813,0.0002110303,0.0002048483,0.0002706172,0.00007467315,0.000357495],"domain_scores_gemma":[0.9991707,0.00002073031,0.0001597768,0.0005424689,0.00007284637,0.00003347535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001769196,0.0002887265,0.08378384,0.000004643328,0.0004683269,0.00006765649,0.0001840589,0.00002639835,0.9087711,0.00003636879,0.00002373368,0.004575937],"study_design_scores_gemma":[0.01474189,0.000952318,0.03372929,0.00004236323,0.00001562889,0.00003979959,0.00001378722,0.00004120699,0.9460786,0.00003492496,0.004142503,0.0001677141],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948968,0.001981945,0.002027691,0.0001218306,0.00009213368,0.0005333644,0.00005015415,0.00002788561,0.0002682436],"genre_scores_gemma":[0.9989598,0.0005587204,0.0001605408,0.00009539117,0.00001861129,0.00003567067,0.00003100299,0.00003079696,0.0001094846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05005454,"threshold_uncertainty_score":0.6102034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01257402064952656,"score_gpt":0.2556890551291387,"score_spread":0.2431150344796121,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}