{"id":"W2759926442","doi":"10.1016/j.omtn.2017.08.017","title":"Control of HIV Infection In Vivo Using Gene Therapy with a Secreted Entry Inhibitor","year":2017,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Sunnybrook Health Science Centre; Sunnybrook Hospital; University of Toronto","funders":"Krembil Foundation; Canadian Institutes of Health Research; Canadian Foundation for AIDS Research","keywords":"Genetic enhancement; Progenitor cell; Ex vivo; Biology; Haematopoiesis; Virology; CD34; In vivo; Gene delivery; Glycoprotein; Viral vector; Stem cell; Immunology; Molecular biology; Gene; Cell biology; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002946876,0.0003081412,0.0002575407,0.0002233661,0.0001453454,0.0007862081,0.0002157701,0.0004462809,0.001244537],"category_scores_gemma":[0.0002163408,0.0001157559,0.0002218316,0.0001443196,0.0004197085,0.0003016209,0.0001537806,0.0009756827,0.0003643172],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003214902,"about_ca_system_score_gemma":0.0004216736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005541518,"about_ca_topic_score_gemma":0.0006889438,"domain_scores_codex":[0.9997984,0.00003390746,0.00001105603,0.00004931404,0.00004995881,0.00005744578],"domain_scores_gemma":[0.9998877,0.00003451698,0.00002967309,0.00001801314,0.000009411926,0.00002064018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001809099,0.00006197063,0.00008640403,0.00003128275,0.000005915228,0.00002957588,0.00002824959,0.000126526,0.9940597,0.000475723,0.00008731279,0.004826499],"study_design_scores_gemma":[0.00009725567,0.001218194,0.0006732576,0.00001286524,0.00002835088,0.0002249835,0.0000236838,0.001932628,0.9922496,0.0001521207,0.003382367,0.000004664382],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9653389,0.008213549,0.02113573,0.0005245396,0.0001829897,0.0001275818,0.0002266212,0.0003116101,0.003938413],"genre_scores_gemma":[0.9881671,0.001713999,0.006110667,0.00007063377,0.00003948217,0.00005766401,0.000153267,0.00003244956,0.003654728],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001244537,"threshold_uncertainty_score":0.004163444,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01257402064952656,"score_gpt":0.2556890551291387,"score_spread":0.2431150344796121,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}