{"id":"W2760003250","doi":"10.3389/fimmu.2017.01215","title":"Coinhibitory Receptor Expression and Immune Checkpoint Blockade: Maintaining a Balance in CD8+ T Cell Responses to Chronic Viral Infections and Cancer","year":2017,"lang":"en","type":"review","venue":"Frontiers in Immunology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; University of Alberta; Alberta Cancer Foundation","keywords":"TIGIT; Blockade; Immune checkpoint; Immunology; Immune system; Cancer immunotherapy; Cancer; Immunotherapy; Medicine; Cytotoxic T cell; T cell; Receptor expression; Cancer research; Receptor; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000656895,0.0004953516,0.002039586,0.0009513575,0.0001823004,0.00004509293,0.0002458829,0.0006971945,0.00007101383],"category_scores_gemma":[0.0001662034,0.0004459685,0.000207162,0.0002655758,0.0004991192,0.0001046606,0.0002709896,0.001050531,0.000006195771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001379653,"about_ca_system_score_gemma":0.0009395438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005704394,"about_ca_topic_score_gemma":0.00009522238,"domain_scores_codex":[0.9973217,0.0003839355,0.0008833594,0.0007035751,0.0001312454,0.0005761586],"domain_scores_gemma":[0.9986474,0.0001216613,0.0004623497,0.0006454022,0.00003465399,0.00008856932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002246227,0.0001316917,0.002372669,0.003417203,0.000270108,0.0000661771,0.000543093,5.45491e-7,0.01662828,0.000002385458,0.0014551,0.9728665],"study_design_scores_gemma":[0.003465049,0.0007232472,0.00191538,0.02425673,0.0001568132,0.000126573,0.0001807779,0.000006160064,0.0008237279,0.00001286836,0.9678742,0.0004585215],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01132684,0.9843798,0.00003974034,0.0002606746,0.002371097,0.001360305,0.00004929354,0.00003387547,0.0001783582],"genre_scores_gemma":[0.001503363,0.9948751,0.0007971266,0.000047532,0.0002226628,0.0006691783,0.00003791446,0.0000691644,0.001777928],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.972408,"threshold_uncertainty_score":0.9997992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02333629337061027,"score_gpt":0.3231009906291114,"score_spread":0.2997646972585011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}