{"id":"W2760003250","doi":"10.3389/fimmu.2017.01215","title":"Coinhibitory Receptor Expression and Immune Checkpoint Blockade: Maintaining a Balance in CD8+ T Cell Responses to Chronic Viral Infections and Cancer","year":2017,"lang":"en","type":"review","venue":"Frontiers in Immunology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; University of Alberta; Alberta Cancer Foundation","keywords":"TIGIT; Blockade; Immune checkpoint; Immunology; Immune system; Cancer immunotherapy; Cancer; Immunotherapy; Medicine; Cytotoxic T cell; T cell; Receptor expression; Cancer research; Receptor; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003916641,0.0004707522,0.0006316798,0.0007600109,0.0001229492,0.0006729696,0.0004492099,0.0008551287,0.0007816495],"category_scores_gemma":[0.0002567473,0.0001259009,0.00031751,0.0005917196,0.000320923,0.0009337371,0.0003836665,0.0009557256,0.0004949239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005251549,"about_ca_system_score_gemma":0.0004215532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000301933,"about_ca_topic_score_gemma":0.0005874215,"domain_scores_codex":[0.9998263,0.0000379404,0.00002282564,0.00003085377,0.00005542598,0.00002670838],"domain_scores_gemma":[0.9998802,0.0000406635,0.00003290136,0.000002671389,0.00002706454,0.00001653343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003789188,0.0001370947,0.001134865,0.01391319,0.0001521805,0.0008738597,0.0001759374,0.000707093,0.0422029,0.005453187,0.02064719,0.9142236],"study_design_scores_gemma":[0.00004466832,0.001290317,0.004971175,0.001728829,0.0002923368,0.006196918,0.0001978163,0.0005744792,0.01426717,0.002533508,0.9678578,0.00004489895],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00200924,0.9958051,0.0005224626,0.0004235845,0.0003377627,0.00000998527,0.00001214024,0.00001339319,0.0008663411],"genre_scores_gemma":[0.007311868,0.9891561,0.0005113744,0.0006741146,0.0008864162,0.00001903108,0.0000433499,0.00000370731,0.001394078],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0008551287,"threshold_uncertainty_score":0.003810346,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02333629337061027,"score_gpt":0.3231009906291114,"score_spread":0.2997646972585011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}