{"id":"W2760006740","doi":"10.1124/jpet.117.243584","title":"Xenobiotic Nuclear Receptors Pregnane X Receptor and Constitutive Androstane Receptor Regulate Antiretroviral Drug Efflux Transporters at the Blood-Testis Barrier","year":2017,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; University of Toronto; Université du Québec à Montréal","funders":"International AIDS Society; University of Toronto; Canadian Institutes of Health Research; Ontario HIV Treatment Network; Canadian Foundation for AIDS Research","keywords":"Pregnane X receptor; Constitutive androstane receptor; Nuclear receptor; Downregulation and upregulation; ATP-binding cassette transporter; Multidrug resistance-associated protein 2; Receptor; Efflux; Transporter; Biology; P-glycoprotein; Abcg2; Pharmacology; Cell biology; Chemistry; Multiple drug resistance; Biochemistry; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002550682,0.0001951915,0.0004398553,0.0004011901,0.0004828009,0.001632265,0.0003015932,0.0003859736,0.003613315],"category_scores_gemma":[0.0004691665,0.0002461052,0.0003974059,0.0002802366,0.0004748348,0.001160786,0.0005054481,0.0006327809,0.0007846872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006634261,"about_ca_system_score_gemma":0.00074064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001723134,"about_ca_topic_score_gemma":0.002148674,"domain_scores_codex":[0.9995426,0.0001445635,0.00002237195,0.0000603574,0.00009882535,0.0001313301],"domain_scores_gemma":[0.9997029,0.00005092084,0.00007906066,0.00002321125,0.00007744304,0.00006646696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009629648,0.0000952986,0.01127161,0.0001817532,0.0001087375,0.0007102956,0.0004131185,0.0004764313,0.9493506,0.01575644,0.001252024,0.01942075],"study_design_scores_gemma":[0.0002203676,0.000909573,0.1439753,0.00008277733,0.0002866751,0.004952346,0.002111136,0.01335379,0.7763378,0.007446668,0.05022012,0.0001033709],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9580966,0.0186828,0.01054857,0.001462859,0.0001430301,0.00005034322,0.0005267134,0.0002684422,0.01022068],"genre_scores_gemma":[0.987468,0.003680456,0.001507968,0.0001428584,0.00003708468,0.00001760499,0.0003579833,0.00005034794,0.00673771],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003613315,"threshold_uncertainty_score":0.01208776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01372634217400993,"score_gpt":0.2871881861510405,"score_spread":0.2734618439770305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}