{"id":"W2760019720","doi":"10.1038/sigtrans.2017.40","title":"Targeting cellular pathways in glioblastoma multiforme","year":2017,"lang":"en","type":"review","venue":"Signal Transduction and Targeted Therapy","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":350,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"John and Lucille Van Geest Foundation; Trent University; Headcase Cancer Trust; Nottingham Trent University","keywords":"Glioblastoma; Medicine; Computational biology; Pathology; Cancer research; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002609036,0.0006773882,0.0008686822,0.001993395,0.0002533522,0.0007069982,0.0005014908,0.0007391474,0.002347437],"category_scores_gemma":[0.0002889933,0.0001947771,0.0003763655,0.001476231,0.000294755,0.0008708386,0.0005244599,0.001425975,0.0016727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005251021,"about_ca_system_score_gemma":0.0006995801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008969696,"about_ca_topic_score_gemma":0.001566259,"domain_scores_codex":[0.999904,0.0000129073,0.00001464992,0.00001434009,0.00004204322,0.000011981],"domain_scores_gemma":[0.9999239,0.00002676714,0.00001337652,0.000002494481,0.00002502218,0.000008359166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006697892,0.00009353927,0.0001512236,0.01867988,0.00006866117,0.0003111298,0.00007147167,0.000458736,0.006286401,0.005932456,0.02558252,0.9422969],"study_design_scores_gemma":[0.00001321714,0.00009320699,0.0004788509,0.002403175,0.00007432066,0.001461409,0.00003773416,0.00009346673,0.001333734,0.00178713,0.9922081,0.00001583602],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002023835,0.9979398,0.0001681642,0.0001859739,0.000165363,0.000007065658,0.00002155583,0.000009053521,0.001300697],"genre_scores_gemma":[0.0008403899,0.9982048,0.0001567326,0.0001312233,0.00006947788,0.000006771562,0.0000315023,0.000001164006,0.0005578838],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002347437,"threshold_uncertainty_score":0.007852972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07417124488464162,"score_gpt":0.3214597366623669,"score_spread":0.2472884917777253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}