{"id":"W2760175736","doi":"10.1002/syn.22014","title":"Proteomic identification of synaptic caspase substrates","year":2017,"lang":"en","type":"article","venue":"Synapse","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Center for Scientific Review; National Institute of Neurological Disorders and Stroke; National Institutes of Health","keywords":"Synapse; Neurodegeneration; Caspase; Biology; Neuroscience; Synaptic plasticity; Cell biology; Proteome; Proteomics; Programmed cell death; Apoptosis; Biochemistry; Disease; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002079844,0.0004967322,0.0004661279,0.0007954873,0.0002409351,0.000399953,0.0003210231,0.0003826445,0.0007275912],"category_scores_gemma":[0.0002701402,0.0001345308,0.0003988975,0.0006619986,0.0001424745,0.0003279771,0.0002769172,0.0005105605,0.0006943667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000243396,"about_ca_system_score_gemma":0.0002443852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004266345,"about_ca_topic_score_gemma":0.000649001,"domain_scores_codex":[0.9998389,0.00001410678,0.00001730131,0.00004340963,0.00005687014,0.00002936668],"domain_scores_gemma":[0.999872,0.00001647519,0.00002195175,0.00001321089,0.00004925859,0.0000271887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006951947,0.0000166815,0.0007854172,0.00009381526,0.00001784464,0.0001322649,0.00001982091,0.00004653654,0.9960219,0.00006116307,0.00008061408,0.002654311],"study_design_scores_gemma":[0.00002766001,0.0002922617,0.05315153,0.00004072693,0.0001170609,0.002806063,0.0001540477,0.002412519,0.9321848,0.0003322769,0.008457185,0.000023895],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.972864,0.008502321,0.0111831,0.0002268673,0.00007554304,0.0001049278,0.004134743,0.0001131434,0.002795345],"genre_scores_gemma":[0.9459285,0.01057668,0.02586659,0.0003354979,0.00005785217,0.0001368278,0.01298069,0.0000611429,0.004056323],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007954873,"threshold_uncertainty_score":0.002434015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01028923685154182,"score_gpt":0.2552474714285675,"score_spread":0.2449582345770257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}