{"id":"W2760175736","doi":"10.1002/syn.22014","title":"Proteomic identification of synaptic caspase substrates","year":2017,"lang":"en","type":"article","venue":"Synapse","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Center for Scientific Review; National Institute of Neurological Disorders and Stroke; National Institutes of Health","keywords":"Synapse; Neurodegeneration; Caspase; Biology; Neuroscience; Synaptic plasticity; Cell biology; Proteome; Proteomics; Programmed cell death; Apoptosis; Biochemistry; Disease; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001408018,0.00006481996,0.00007138201,0.00001865082,0.0001206295,0.00002768407,0.0001555367,0.00008726475,0.00001528459],"category_scores_gemma":[0.00006686935,0.00005847712,0.00004668182,0.00001120773,0.00007204196,0.00000438545,0.00004465082,0.00002597034,0.00001082644],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004260767,"about_ca_system_score_gemma":0.00002456962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003304566,"about_ca_topic_score_gemma":0.00001364894,"domain_scores_codex":[0.9995228,0.00001486007,0.0001522677,0.0001623622,0.00005912456,0.00008855439],"domain_scores_gemma":[0.999226,0.000001679533,0.0001947558,0.0004933905,0.00005647276,0.00002772833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002156967,0.00002286807,0.0007734291,0.00001930692,0.0000233456,0.000001533305,0.00001252498,0.00002640785,0.9974159,0.0005281941,0.00004638016,0.001108543],"study_design_scores_gemma":[0.0001901209,0.00007348476,0.0341244,0.000007811228,0.00001473169,0.000007846778,0.00001180599,0.000227086,0.9646642,0.0004735126,0.0001318629,0.00007315468],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982934,0.0001164742,0.000968147,0.00007250069,0.0001149269,0.0001723776,0.000008455159,0.000004867128,0.0002488705],"genre_scores_gemma":[0.9988598,0.00006264765,0.000166414,0.000005834484,0.00006937695,0.00001512848,0.00004945717,0.000008565044,0.0007627893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03335097,"threshold_uncertainty_score":0.2384628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01028923685154182,"score_gpt":0.2552474714285675,"score_spread":0.2449582345770257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}