{"id":"W2760263378","doi":"10.1177/2472555217733421","title":"A Screening System for Evaluating Cell Extension Formation, Collagen Compaction, and Degradation in Drug Discovery","year":2017,"lang":"en","type":"article","venue":"SLAS DISCOVERY","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Ontario Institute for Cancer Research; California HIV/AIDS Research Program","keywords":"Chemistry; Fibroblast; Cell; Matrix (chemical analysis); Cell culture; Cell biology; Collagen receptor; Cancer cell; Integrin; Cancer; Biochemistry; Biology; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003436271,0.0001177585,0.0001263524,0.00005399835,0.000437201,0.0003870573,0.0001097753,0.00006224616,0.000001307275],"category_scores_gemma":[0.0001149975,0.0001147026,0.00006621299,0.00002727263,0.00002246968,0.0001522085,0.00009737508,0.00004325064,0.000001291353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000038518,"about_ca_system_score_gemma":0.00004259757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001663311,"about_ca_topic_score_gemma":0.0003990173,"domain_scores_codex":[0.9991949,0.00004101881,0.0002317744,0.0002674947,0.0001052892,0.0001595556],"domain_scores_gemma":[0.999288,0.00002234096,0.0002331905,0.0003410758,0.00008107811,0.0000343768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001907772,0.00004893496,0.001279585,0.0001344647,0.00002058368,0.000001252487,0.00009659116,0.000288336,0.9944323,0.001083719,0.001020083,0.001403361],"study_design_scores_gemma":[0.002747145,0.0003302633,0.009418369,0.0003607296,0.00008128562,0.00003996224,0.002989718,0.05966279,0.9190425,0.0004181705,0.004422397,0.0004866835],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8699758,0.0002440039,0.1285155,0.00007013995,0.0002960446,0.000367895,0.00004356179,0.000006909518,0.000480178],"genre_scores_gemma":[0.9967223,0.00006211883,0.001159527,0.00003160925,0.000112092,0.00004925318,0.0002748317,0.00001770968,0.001570495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.127356,"threshold_uncertainty_score":0.4677438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02920388920767578,"score_gpt":0.3013513071302724,"score_spread":0.2721474179225967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}