{"id":"W2760263378","doi":"10.1177/2472555217733421","title":"A Screening System for Evaluating Cell Extension Formation, Collagen Compaction, and Degradation in Drug Discovery","year":2017,"lang":"en","type":"article","venue":"SLAS DISCOVERY","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Ontario Institute for Cancer Research; California HIV/AIDS Research Program","keywords":"Chemistry; Fibroblast; Cell; Matrix (chemical analysis); Cell culture; Cell biology; Collagen receptor; Cancer cell; Integrin; Cancer; Biochemistry; Biology; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007321091,0.0008384755,0.0005598833,0.000875625,0.0003802077,0.0003732768,0.0004028077,0.0006460232,0.001888526],"category_scores_gemma":[0.0003967387,0.0003329612,0.0004070195,0.0006020616,0.0002843108,0.0003427338,0.0004076032,0.0006658635,0.0005504367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003403393,"about_ca_system_score_gemma":0.0004351879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009024677,"about_ca_topic_score_gemma":0.002577267,"domain_scores_codex":[0.9992437,0.0002225663,0.00005403196,0.0001295894,0.0002856037,0.00006437705],"domain_scores_gemma":[0.9994198,0.0001874715,0.0001239933,0.0000902334,0.00008312031,0.00009536984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007511237,0.00006906233,0.0001949157,0.00004585038,0.0000120892,0.00003391959,0.00001068839,0.0001271583,0.9969743,0.00006226732,0.0001046996,0.00228985],"study_design_scores_gemma":[0.00009215075,0.002621643,0.005150303,0.00002109622,0.00008294923,0.0005093719,0.00002640171,0.002656621,0.985636,0.00007905325,0.003101256,0.00002313893],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8072973,0.004320969,0.1761056,0.0003468146,0.000185395,0.001082334,0.003270382,0.001307974,0.006083257],"genre_scores_gemma":[0.826164,0.004228731,0.1533505,0.0003118195,0.00006939007,0.001949419,0.00490337,0.000114321,0.008908354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001888526,"threshold_uncertainty_score":0.006317735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02920388920767578,"score_gpt":0.3013513071302724,"score_spread":0.2721474179225967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}