{"id":"W2760341058","doi":"10.1016/j.cjca.2017.07.324","title":"ESTABLISHMENT OF STABLE IN VITRO CARDIAC MODELS OF KEARNS-SAYRE SYNDROME USING INDUCED PLURIPOTENT STEM CELL TECHNOLOGY","year":2017,"lang":"en","type":"article","venue":"Canadian Journal of Cardiology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Research Manitoba","funders":"","keywords":"Induced pluripotent stem cell; Mitochondrial disease; Medicine; Reprogramming; Kearns–Sayre syndrome; Mitochondrion; Mitochondrial myopathy; Stem cell; Peripheral blood mononuclear cell; Bioinformatics; Internal medicine; In vitro; Cell; Mitochondrial DNA; Cell biology; Biology; Genetics; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008649679,0.0005669384,0.0005077701,0.001096221,0.0004864314,0.0007059756,0.0008196973,0.000787191,0.002765829],"category_scores_gemma":[0.0006592645,0.0004005385,0.0005855692,0.0003348939,0.000395257,0.0005952442,0.0005680448,0.001396986,0.0011763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003669455,"about_ca_system_score_gemma":0.0004279732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007225471,"about_ca_topic_score_gemma":0.001931526,"domain_scores_codex":[0.9994037,0.00008126612,0.0001294299,0.00009703267,0.0002052517,0.00008335021],"domain_scores_gemma":[0.9993184,0.0001519965,0.0001778178,0.0001427354,0.00008016572,0.0001289422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000141931,0.0001216032,0.0005043687,0.00006240474,0.00002726698,0.0008450727,0.0001473671,0.0003248577,0.9937883,0.001951993,0.0001980814,0.001886831],"study_design_scores_gemma":[0.0001323721,0.0007223983,0.003739073,0.00003763345,0.0001277264,0.002483424,0.0001737808,0.00323426,0.979309,0.0003443333,0.009672808,0.00002311626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9472792,0.00212667,0.03934189,0.0004076884,0.0004456236,0.0005868485,0.001867806,0.0004434723,0.007500876],"genre_scores_gemma":[0.9706936,0.001668216,0.01643079,0.0001107113,0.00004883533,0.0004098903,0.002278347,0.0001178806,0.008241767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002765829,"threshold_uncertainty_score":0.009252608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02357134119459287,"score_gpt":0.2294764432866814,"score_spread":0.2059051020920885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}