{"id":"W2760436846","doi":"10.1212/wnl.0000000000004560","title":"<i>COL4A2</i> is associated with lacunar ischemic stroke and deep ICH","year":2017,"lang":"en","type":"review","venue":"Neurology","topic":"Cerebrovascular and genetic disorders","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hamilton Health Sciences; McMaster University; Population Health Research Institute; Health Sciences Centre","funders":"National Center for Advancing Translational Sciences; Canadian Institutes of Health Research; National Institutes of Health; National Institute on Aging; Stiftung zur Erforschung der Vaskulären Demenz; National Institute of Neurological Disorders and Stroke; National Institute for Health and Care Research; Bundesministerium für Bildung und Forschung; National Institute of Diabetes and Digestive and Kidney Diseases; Lunds Universitet; Deutsche Forschungsgemeinschaft; Cambridge University Hospitals; Fondation Leducq; STROKE-Riksförbundet; European Commission; University of Cambridge; National Heart, Lung, and Blood Institute; Canadian Stroke Network","keywords":"Lacunar stroke; Odds ratio; Single-nucleotide polymorphism; Linkage disequilibrium; Medicine; Confidence interval; SNP; Stroke (engine); Intracerebral hemorrhage; Locus (genetics); Internal medicine; Ischemic stroke; Cardiology; Pathology; Genotype; Genetics; Biology; Gene; Ischemia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001836134,0.0007576293,0.0009666953,0.00106462,0.0005511942,0.000981465,0.0007497286,0.000854453,0.00312103],"category_scores_gemma":[0.003224864,0.0004091637,0.005675538,0.002035683,0.0004397446,0.0002770403,0.0006536084,0.0006028248,0.0001817932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003581914,"about_ca_system_score_gemma":0.000531874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01737679,"about_ca_topic_score_gemma":0.01713595,"domain_scores_codex":[0.9986538,0.000352698,0.0001444196,0.0005436329,0.0001553124,0.0001500544],"domain_scores_gemma":[0.9977654,0.0008676208,0.0006402793,0.0003499329,0.0001829045,0.000193782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003824087,0.00003339885,0.9411157,0.0005160526,0.04229273,0.0004891867,0.00008524558,0.0007524624,0.003765035,0.000125229,0.0009709532,0.006029803],"study_design_scores_gemma":[0.0002462436,0.0002654074,0.9602517,0.0001492286,0.0332239,0.0006976209,0.0001265918,0.002266126,0.00132879,0.0002779672,0.001143227,0.00002317079],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9761041,0.01648648,0.002400437,0.0005971534,0.0001832462,0.00004078167,0.002448448,0.0001090568,0.0016303],"genre_scores_gemma":[0.9974931,0.000727051,0.0005975718,0.000127851,0.00006804426,0.00001564921,0.0005890877,0.00001500458,0.0003667075],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.01737679,"threshold_uncertainty_score":0.03455126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03253750744653255,"score_gpt":0.3083116632505654,"score_spread":0.2757741558040329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}