{"id":"W2760458695","doi":"10.1084/jem.20171129","title":"ICAMs support B cell interactions with T follicular helper cells and promote clonal selection","year":2017,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Horizon 2020 Framework Programme; Benoziyo Endowment Fund for the Advancement of Science; Irma und Jacques Ber-Lehmsdorf - Stiftung; Azrieli Foundation; Human Frontier Science Program; H2020 European Research Council; Rising Tide Foundation; Gerald O. Mann Charitable Foundation","keywords":"Germinal center; B cell; Biology; Antigen; Cell biology; Naive B cell; Affinity maturation; CD40; Cell; Antigen presentation; Immune system; Antibody; T cell; Immunology; Antigen-presenting cell; Cytotoxic T cell; In vitro; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003260799,0.000152744,0.0002856295,0.00006913544,0.0005363015,0.00001408917,0.000273119,0.00007954875,0.0009788356],"category_scores_gemma":[0.0000147076,0.00007802472,0.00004594334,0.00003104579,0.0007046646,0.0001615907,0.00007418328,0.0004367575,0.00004733149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000035698,"about_ca_system_score_gemma":0.00003873637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001091959,"about_ca_topic_score_gemma":0.0000105724,"domain_scores_codex":[0.9992033,0.000119305,0.0003009162,0.0001111674,0.0000635163,0.0002017881],"domain_scores_gemma":[0.99914,0.00006127406,0.0004735568,0.0002108485,0.00007911913,0.00003526195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006961303,0.0002053304,0.0002908973,0.000004404612,0.0001652106,0.00001880391,0.001636027,7.831859e-7,0.9931832,0.00002376413,0.003404584,0.0003708988],"study_design_scores_gemma":[0.003010518,0.003313036,0.000436028,0.00006570758,0.0001352392,0.003264921,0.001896614,0.000002313392,0.9624694,0.00001887252,0.02529714,0.00009020331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919086,0.003566418,0.00008132073,0.001466369,0.00105556,0.0001420446,0.000001779735,0.000008679523,0.001769222],"genre_scores_gemma":[0.9953024,0.0002269895,0.00008238831,0.0001662345,0.000164528,0.000003129215,0.000003836197,0.00001282031,0.004037723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03071376,"threshold_uncertainty_score":0.9999344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01271251996278554,"score_gpt":0.2675653130590349,"score_spread":0.2548527930962494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}