{"id":"W2760611030","doi":"10.1016/j.cjca.2017.07.330","title":"DIRECT EFFECTS OF EMPAGLIFLOZIN ON EXTRACELLULAR MATRIX REMODELING IN HUMAN CARDIAC FIBROBLASTS: NOVEL TRANSLATIONAL CLUES TO EMPA-REG OUTCOME","year":2017,"lang":"en","type":"article","venue":"Canadian Journal of Cardiology","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"Calgary Laboratory Services","funders":"","keywords":"Empagliflozin; Medicine; Extracellular matrix; EMPA; Fibroblast; Myofibroblast; Heart failure; Ventricular remodeling; Cell biology; Internal medicine; Cancer research; Endocrinology; Chemistry; Fibrosis; Biology; Biochemistry; Diabetes mellitus; In vitro; Type 2 diabetes","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004143969,0.0002447337,0.0002898244,0.0001563974,0.0001945071,0.0005305611,0.0001475312,0.0002803451,0.001879411],"category_scores_gemma":[0.0002365355,0.0001055898,0.0003600736,0.0001133341,0.0002592418,0.0002763628,0.0002342205,0.0009638467,0.0002582555],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002176459,"about_ca_system_score_gemma":0.0002832856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004561578,"about_ca_topic_score_gemma":0.001018887,"domain_scores_codex":[0.9998493,0.00002901098,0.00001268175,0.00002384622,0.00004023277,0.00004486907],"domain_scores_gemma":[0.9999282,0.00001657869,0.00001562598,0.000009848382,0.00001105032,0.00001863843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001886509,0.0003930939,0.002397059,0.0002892202,0.0000773262,0.0004080282,0.00009513907,0.0002887234,0.9567299,0.0009646427,0.001175442,0.03529488],"study_design_scores_gemma":[0.0005242256,0.004276949,0.04549376,0.00004451844,0.000268584,0.001110781,0.0003018225,0.001928861,0.9334419,0.000609603,0.01197749,0.00002145579],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9771708,0.01182935,0.003348998,0.001466232,0.0002578027,0.00006767218,0.0006450554,0.00008449065,0.005129651],"genre_scores_gemma":[0.992459,0.003558593,0.001262604,0.0002864493,0.00006268236,0.00003882398,0.0003552217,0.000007326056,0.001969287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001879411,"threshold_uncertainty_score":0.006287277,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02805714148924011,"score_gpt":0.3189471138115693,"score_spread":0.2908899723223292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}