{"id":"W2760644379","doi":"10.1039/c7ob02289a","title":"Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety","year":2017,"lang":"en","type":"article","venue":"Organic & Biomolecular Chemistry","topic":"Fluorine in Organic Chemistry","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministero dello Sviluppo Economico; Fundação de Amparo à Pesquisa do Estado de São Paulo; European Federation of Pharmaceutical Industries and Associations; Novartis Pharma; Swansea University; Wellcome Trust; Ontario Ministry of Economic Development and Innovation; Engineering and Physical Sciences Research Council; Genome Canada; Pfizer","keywords":"Chemistry; Moiety; Kinase; Combinatorial chemistry; Stereochemistry; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001596481,0.0004546495,0.000226249,0.0001788415,0.0001248326,0.0001559227,0.0002934512,0.000220624,0.001894015],"category_scores_gemma":[0.0001136125,0.0001582288,0.0002011821,0.0001370004,0.00009360127,0.0001809127,0.000143696,0.0003984411,0.0004869711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002280189,"about_ca_system_score_gemma":0.0003076216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006300344,"about_ca_topic_score_gemma":0.001638779,"domain_scores_codex":[0.9999195,0.00001207772,0.000007386346,0.00001011459,0.00001761964,0.00003327267],"domain_scores_gemma":[0.9999526,0.000006419337,0.00001556132,0.000004701829,0.000009182885,0.00001157098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002532172,0.0001676424,0.0001524497,0.0002419218,0.0000247807,0.0003684264,0.00006306082,0.0009676197,0.9786931,0.001580304,0.0006912319,0.01679625],"study_design_scores_gemma":[0.00009997284,0.001287808,0.0009997785,0.00001823989,0.00003514655,0.0005336058,0.00001851228,0.001027723,0.9791157,0.0001307463,0.01671453,0.00001815069],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9255195,0.007871726,0.03652701,0.0003634356,0.0001951883,0.0005432816,0.001628617,0.0004962616,0.02685499],"genre_scores_gemma":[0.9734432,0.003483963,0.01334858,0.00009954333,0.00002508458,0.0001643068,0.000961114,0.00003336918,0.008440933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001894015,"threshold_uncertainty_score":0.006336153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0386081177397147,"score_gpt":0.3638775799622798,"score_spread":0.3252694622225651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}