{"id":"W2760657482","doi":"10.1080/15548627.2017.1370171","title":"Oncogenic RAS-induced downregulation of ATG12 is required for survival of malignant intestinal epithelial cells","year":2017,"lang":"en","type":"article","venue":"Autophagy","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research","keywords":"ATG12; Biology; ATG5; Autophagy; Cell biology; Cancer research; Effector; Small GTPase; Cancer cell; Downregulation and upregulation; Cancer; Apoptosis; Signal transduction; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009349522,0.0001689434,0.0002491555,0.0001764957,0.0001728804,0.0002026273,0.0001086529,0.0001430029,0.000743486],"category_scores_gemma":[0.00009720759,0.00008927014,0.000194771,0.0001351745,0.000163477,0.0001384843,0.0001852411,0.000348331,0.0003020692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002095156,"about_ca_system_score_gemma":0.0001731881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003306731,"about_ca_topic_score_gemma":0.0006683876,"domain_scores_codex":[0.9999001,0.00001620754,0.00001572028,0.00001290614,0.00003155857,0.00002344285],"domain_scores_gemma":[0.9999022,0.00001381764,0.00002566321,0.00001632052,0.00001773801,0.00002426997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007148656,0.00001179313,0.0003134344,0.00003102187,0.000003399662,0.00008317631,0.00001048297,0.00002238047,0.9983063,0.00009392673,0.00002930551,0.001023282],"study_design_scores_gemma":[0.000007275691,0.0001047953,0.009226322,0.000003772178,0.0000129369,0.0005030605,0.00002878033,0.0004477922,0.9858926,0.00004136747,0.003728655,0.000002669666],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942367,0.002116998,0.001948519,0.0001261172,0.00001984735,0.00001651341,0.0002412082,0.00009296071,0.001201265],"genre_scores_gemma":[0.9973072,0.0005749722,0.00084409,0.00002006645,0.000004083074,0.00001253989,0.0002484333,0.000008597565,0.0009801486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000743486,"threshold_uncertainty_score":0.002487183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05046315864514727,"score_gpt":0.3346300492206754,"score_spread":0.2841668905755281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}