{"id":"W2760662626","doi":"10.1158/2326-6066.cir-17-0131","title":"Treg Depletion Licenses T Cell–Driven HEV Neogenesis and Promotes Tumor Destruction","year":2017,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":129,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; Cardiff University; Canolfan Ymchwil Canser Cymru; National Cancer Institute; National Institutes of Health; Cancer Research UK; Wellcome Trust; Deutsches Krebsforschungszentrum; Genentech; American Association for Cancer Research","keywords":"High endothelial venules; Immune system; Tumor microenvironment; Cancer research; Biology; Immunology; FOXP3; T cell; CD8; Chemokine receptor; Chemokine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002047164,0.0002899399,0.0002517553,0.0004263489,0.0001500988,0.0003344976,0.0002234733,0.0002702812,0.00249896],"category_scores_gemma":[0.0001264622,0.0001172829,0.0002418488,0.0001312847,0.000295457,0.0001550891,0.0002243113,0.00106732,0.0007219428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002627103,"about_ca_system_score_gemma":0.0002445019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007658175,"about_ca_topic_score_gemma":0.001007301,"domain_scores_codex":[0.9996672,0.00006939848,0.00002549733,0.00005653028,0.00007856622,0.0001028902],"domain_scores_gemma":[0.9997913,0.00004533473,0.00004340615,0.00004764174,0.00001238393,0.00005990174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000260484,0.0003382237,0.0003664895,0.00005198161,0.000009634779,0.0001167801,0.00001886661,0.0002155712,0.9922404,0.0005302934,0.0005040652,0.005347252],"study_design_scores_gemma":[0.0001081236,0.001159721,0.003913271,0.00001548423,0.00001658516,0.0004810797,0.00003377247,0.003772815,0.9828911,0.000170249,0.00743238,0.000005323973],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855026,0.001935158,0.004429786,0.0001843285,0.0001278005,0.0001020371,0.0005538386,0.0004597454,0.006704702],"genre_scores_gemma":[0.9935231,0.0004628017,0.001351034,0.00008188732,0.00002379367,0.00005855555,0.0004044111,0.00004413527,0.004050167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00249896,"threshold_uncertainty_score":0.008359849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05112450620899809,"score_gpt":0.3304144351590331,"score_spread":0.279289928950035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}