{"id":"W2760729545","doi":"10.4049/jimmunol.1700643","title":"PD-1 Blockade Promotes Epitope Spreading in Anticancer CD8+ T Cell Responses by Preventing Fratricidal Death of Subdominant Clones To Relieve Immunodomination","year":2017,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; Prostate Cancer Canada; Movember Foundation","keywords":"Subdominant; Blockade; Cytotoxic T cell; Epitope; CD8; Biology; Cell biology; Cancer research; Immunology; Genetics; Immune system; Antibody; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007794406,0.0002168221,0.0001989079,0.0001100441,0.00008640706,0.0001826376,0.0001201348,0.0001300193,0.0008820246],"category_scores_gemma":[0.0001053163,0.00008581069,0.00010635,0.00006046712,0.000131491,0.0001152233,0.0001292453,0.000754921,0.0002143775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001434506,"about_ca_system_score_gemma":0.0001420633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000165178,"about_ca_topic_score_gemma":0.0002272298,"domain_scores_codex":[0.9999138,0.00001133847,0.00000727684,0.00001897614,0.00001587092,0.00003279668],"domain_scores_gemma":[0.9999136,0.00001936148,0.00001552487,0.00001147359,0.000007456227,0.00003254095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003008151,0.0001795367,0.0001916279,0.00002200052,0.00000283674,0.00002127314,0.00001383495,0.0002364548,0.9963606,0.00008565793,0.00004407333,0.002541198],"study_design_scores_gemma":[0.00005624243,0.001599385,0.0020269,0.000004073574,0.000008901645,0.0001349041,0.00001518044,0.003231723,0.9920344,0.00005914725,0.0008264126,0.000002737331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985126,0.0002126066,0.0007806933,0.0000170272,0.000008503769,0.00001224043,0.00003094292,0.00002730958,0.0003981702],"genre_scores_gemma":[0.99855,0.00007923352,0.0006610386,0.00001884296,0.000005806594,0.00001363681,0.00005370716,0.000007126203,0.0006106425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008820246,"threshold_uncertainty_score":0.002950668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01328697652192789,"score_gpt":0.2750165703317027,"score_spread":0.2617295938097748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}