{"id":"W2760823644","doi":"10.1158/2159-8290.cd-17-0267","title":"TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia","year":2017,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Beatrice Hunter Cancer Research Institute; Dalhousie University","funders":"National Cancer Institute; National Institutes of Health","keywords":"Ku70; Genome instability; Ku80; Biology; Cancer research; DNA repair; Carcinogenesis; Cell growth; Cell biology; DNA damage; Cancer; Genetics; Molecular biology; DNA; Gene; DNA-binding protein; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008020517,0.0002073172,0.0001571281,0.0003186338,0.0001663445,0.0003383774,0.000129407,0.0001832788,0.001343605],"category_scores_gemma":[0.00007546465,0.000118736,0.0001241899,0.0001951037,0.0001914936,0.00009508339,0.0002245825,0.0003165636,0.0004181801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005276441,"about_ca_system_score_gemma":0.0002577237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008675667,"about_ca_topic_score_gemma":0.001737227,"domain_scores_codex":[0.9999164,0.000009115082,0.000003636003,0.00001464063,0.00003524675,0.00002085252],"domain_scores_gemma":[0.9999423,0.00000616898,0.00002774777,0.000002611635,0.000005980538,0.00001516109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002070251,0.00003981324,0.002165428,0.00003878899,0.000005803062,0.0002242447,0.00002359355,0.0001499235,0.9917188,0.0003607257,0.0004450767,0.004620771],"study_design_scores_gemma":[0.00009082683,0.0006602574,0.1341854,0.00002437015,0.00006949936,0.001703225,0.0002016531,0.003620637,0.8396891,0.0005408867,0.01919261,0.00002165245],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987064,0.005136971,0.001786985,0.0003106318,0.00004301869,0.00002012747,0.0008583867,0.0002644746,0.004515351],"genre_scores_gemma":[0.9926797,0.002030737,0.0005240153,0.00005679831,0.00001188702,0.00001242249,0.0005751912,0.00002891701,0.004080308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001343605,"threshold_uncertainty_score":0.004494846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008920916745991566,"score_gpt":0.248211428761017,"score_spread":0.2392905120150254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}