{"id":"W2760823644","doi":"10.1158/2159-8290.cd-17-0267","title":"TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia","year":2017,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Beatrice Hunter Cancer Research Institute; Dalhousie University","funders":"National Cancer Institute; National Institutes of Health","keywords":"Ku70; Genome instability; Ku80; Biology; Cancer research; DNA repair; Carcinogenesis; Cell growth; Cell biology; DNA damage; Cancer; Genetics; Molecular biology; DNA; Gene; DNA-binding protein; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001430342,0.0001403746,0.0001484654,0.00002744446,0.0001323705,0.00009603439,0.0001686871,0.000126315,0.000006090253],"category_scores_gemma":[0.00006160502,0.0001364326,0.00006596853,0.00002379434,0.0001497427,0.00002141395,0.0001951936,0.00005617833,0.000001633554],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001127565,"about_ca_system_score_gemma":0.0002089578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003680964,"about_ca_topic_score_gemma":0.0005285801,"domain_scores_codex":[0.9991009,0.00003128229,0.0001844835,0.0004139225,0.00007014398,0.0001993186],"domain_scores_gemma":[0.9992554,0.00001180973,0.0001087614,0.0005308407,0.00003487957,0.00005836431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008932694,0.00002093475,0.1830585,0.00004302054,0.00002650946,0.000003360996,0.00004029201,0.0001032614,0.8154954,0.00002993474,0.0000797801,0.001009646],"study_design_scores_gemma":[0.0007303547,0.00007933733,0.4457254,0.00002223956,0.00002753835,9.3611e-7,0.00001669852,0.0001205812,0.5518195,0.0005160723,0.0007510594,0.0001903164],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943893,0.004102102,0.0001539578,0.00005439614,0.0002130561,0.0001424353,0.00004288652,0.000007532038,0.0008943204],"genre_scores_gemma":[0.9947829,0.004141917,0.0001372057,0.00005634709,0.0001534163,0.00002889091,0.00002876564,0.00001851951,0.0006519911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2636759,"threshold_uncertainty_score":0.556356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008920916745991566,"score_gpt":0.248211428761017,"score_spread":0.2392905120150254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}